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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
ProteomicsA pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease
Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA. Nat Biotechnol. 2011, 29(7):635-43. doi: 10.1038/nbt.1899. PMCID:PMC3366591. Discovery, AIMS, and MRM datasets Discovery_Tranche_hash: b/quYtp/Q8fY...
2013-12-19 | MSV000078513 | MassIVE
MetabolomicsUntargeted metabolomics analyses and contaminant chemistry of Dreissenid mussels at the Maumee River Area of Concern in the Great Lakes

Bivalves serve as an ideal ecological indicator; hence, their use by the NOAA Mussel Watch Program to monitor environmental health. This study aimed to expand the baseline knowledge of using metabolic end points in environmental monitoring by investigating the dreissenid mussel metabolome in the ...

2024-06-03 | MTBLS6311 | MetaboLights
TranscriptomicsTranscription profiling of brain hemispheres from R6/2 transgenic mice treated with a combination drug therapy (tacrine, moclobemide and creatine) to study the molecular impact of the drug therapy on Huntingtons disease.
Huntington's disease is a genetic disease caused by a single mutation. It is characterised by progressive movement, emotional and cognitive deficits. R6/2 transgenic mice carrying the Huntington's disease mutation have a progressive neurological phenotype, including deterioration in cognitive functi...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-857 | biostudies-arrayexpress
UnknownReducing COPD Readmission Rates: Using a COPD Care Service During Care Transitions.
Not available
S-EPMC6366592 | biostudies-literature
GenomicsFusobacterium nucleatum subsp. nucleatum ATCC 25586
Fusobacterium nucleatum subsp. nucleatum ATCC 25586 Genome sequencing
PRJNA1437796 | ENA
UnknownRapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-58464 | biostudies-other
ProteomicsHighly multiplexed quantification by targeted mass spectrometry to triage protein candidate biomarkers in plasma
Despite improvements in capabilities of proteomics technologies, the introduction of new plasma-based protein biomarkers for clinical use remains low. One reason is the cumbersome requirement to test thousands of protein candidates in follow-up quantitative verification studies. We sought to evaluat...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-29 | PXD028306 | Pride
Human Breast cancer Plasma Is-prm Protein Lc-ms/ms 
Transcriptomics17beta-estradiol (E2)-regulated gene expression across time in estrogen-dependent and estrogen deprivation-resistant MCF-7-derived breast cancer cell lines.
A series of MCF-7 variants were previously developed that are either estrogen-dependent for growth (MCF-7:WS8 cells), or resistant to estrogen deprivation and refractory (MCF-7:2A) or sensitive (MCF-7:5C) to E2-induced apoptosis. To identify genes associated with E2-induced apoptosis, estrogen depri...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-29917 | biostudies-arrayexpress
TranscriptomicsRapid isolation of extracellular vesicles from cell culture and biological fluids using a synthetic peptide with specific affinity for heat shock proteins
Background: Exosomes and extracellular vesicles (EVs) are increasingly recognized as important sources of biomarkers for disease study and diagnosis. Results: A synthetic peptide, Vn96, allows for capture of EVs from biological fluids using basic laboratory equipment. Conclusion: The Vn96-captured E...
ORGANISM(S): Homo sapiens 
2014-06-14 | E-GEOD-58464 | biostudies-arrayexpress
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