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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
TranscriptomicsTranscription profiling of rat kidney iosgrafts from live or brain dead donors with samples taken before and after transplantation
The clinical results obtained with organ allografts from marginal or extended donors are less satisfactory over both the short-term and long-term than the outcome of grafting from living donors. Early postoperative graft function depends on several pretransplant factors, with the major donor influen...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-5104 | biostudies-arrayexpress
UnknownUnderstanding how Lewis acids dope organic semiconductors: a "complex" story.
Not available
S-EPMC8153436 | biostudies-literature
TranscriptomicsTranscriptome analysis of a Bacillus subtilis mutant defective in the transcription termination factor Rho.
This analysis is part of the study GSE27219, The condition-dependent transcriptome of Bacillus subtilis 168. In this study, 120 transcription units where identified for which transcription did not terminate at any specific site, leading to mRNA extension over long distances with slowly decreasing si...
ORGANISM(S): Bacillus subtilis 
2012-03-07 | E-GEOD-27303 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptome and TCR repertoire of PD-1 fate-mapped immune cells during cyclophosphamide and PD-1 blockade in syngeneic subcutaneous LLC tumor allografts
Processed single-cell datasets from Pdcd1-CreERT2 × Rosa26-tdTomato fate-mapping mice bearing subcutaneous LLC allografts and treated with CTX, anti-PD-1, or both. We provide count matrices, cell-level annotations, and per-cell TCR clonotypes; raw reads for transcriptome, sample-tag, and TCR librari...
ORGANISM(S): Mus musculus 
2026-03-11 | E-MTAB-15883 | biostudies-arrayexpress
MetabolomicsPrediction and evaluation of the effect of pre-centrifugation sample management on the measurable untargeted LC-MS plasma metabolome

Optimal handling is the most important means to ensure adequate sample quality. We aimed to investigate whether pre-centrifugation delay time and temperature could be accurately predicted and to what extent variability induced by pre-centrifugation management can be adjusted for. We used untarget...

2021-10-13 | MTBLS2259 | MetaboLights
TranscriptomicsVirulence effects and signaling partners modulated by Brucella melitensis light-sensing histidine kinase
A whole genome expression comparision between wild type B. melitensis 16M and M-NM-^TBM-LOV-HK (M-NM-^TBMEII0679) B. melitensis strains grown in broth culture to determine genes directly and indirectly regulated by BM-LOV-HK. 6 samples, 3 wild type B. melitensis 16M replicates, 3 M-NM-^TBM-LOV-HK B....
ORGANISM(S): Brucella melitensis bv. 1 str. 16M 
2013-06-15 | E-GEOD-42599 | biostudies-arrayexpress
ProteomicsQuantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity. Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited nu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-10-07 | MSV000084429 | MassIVE
TranscriptomicsRNA sequencing of monocytes and microglia from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course
The role of microglia and infiltrating monocytes in experimental autoimmune encephalomyelitis (EAE) pathogenesis has been controversial. To gain insight into their respective roles, we developed a method for differentiating between microglia and infiltrating monocytes in the CNS using CD44. We used ...
ORGANISM(S): Mus musculus 
2014-10-20 | E-GEOD-59725 | biostudies-arrayexpress
UnknownEnvironmental Changes Recorded in Sedimentary Rocks in the Clay-Sulfate Transition Region in Gale Crater, Mars: Results From the Sample Analysis at Mars-Evolved Gas Analysis Instrument Onboard the Mars Science Laboratory Curiosity Rover.
Not available
S-EPMC11603101 | biostudies-literature
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