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ProteomicsSM/J mice display spontaneous early onset disc degeneration link to ion transport system and matrisome changes
To fully apprehend the complex mechanisms responsible for intervertebral disc (IVD) degeneration, one needs to gain a deeper understanding of what characterizes a good and bad intervertebral disc. Using a quantitative proteomic approach, we compared methodically the differences existing between a mo...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-16 | PXD008784 | Pride
Mouse intervertebral disc Nucleus pulposus Lg/j and sm/j. Proteomic 
TranscriptomicsGene expression in soleus muscle of mouse inbred strains LG/J and SM/J
Variability in muscle mass significantly impacts energy expenditure, influencing preponderance to obesity and recently it has been reported that there is a positive association between muscle mass and longevity in older adults. Muscle fibre cross-sectional area (CSA) and proportion of different fibr...
ORGANISM(S): Mus musculus 
2017-01-23 | E-MTAB-5290 | biostudies-arrayexpress
TranscriptomicsHigh-Low Fat Diet/Strain Experiment
Males and females from each SM/J and LG/J were placed on either a low-fat diet or high-fat diet immediately after weaning until 20 weeks of age. At 20 weeks, mice were sacrificed in late morning after a four-hour fast and liver tissue was collected from 4 males and 4 females from each strain and die...
ORGANISM(S): Mus musculus 
2014-01-30 | E-MTAB-2172 | biostudies-arrayexpress
TranscriptomicsGenetic Loci that Regulate Ectopic Calcification in Response to Knee Trauma in LG/J by SM/J Advanced Intercross Mice
Ectopic calcification in synovial tissues is devastating to diarthrodial joints. While some forms of synovial ectopic calcification have genetically simple basis, most cases manifest as complex traits with environmental and multigenic components. The location of causal loci or the physiological proc...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-64793 | biostudies-arrayexpress
TranscriptomicsGenetic loci that regulate healing and regeneration in LG/J and SM/J mice
MRL mice display unusual healing properties. When MRL ear pinnae are hole punched, the holes close completely without scarring, with re-growth of cartilage, and reappearance of both hair follicles and sebaceous glands. Studies using (MRL/lpr x C57BL/6)F2 and backcross mice first showed that this phe...
ORGANISM(S): Mus musculus 
2009-07-27 | GSE17168 | GEO
UnknownRNA-seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains.
Not available
S-EPMC7108965 | biostudies-literature
UnknownThe effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice.
Not available
S-EPMC4028868 | biostudies-literature
UnknownGenetic loci that regulate healing and regeneration in LG/J and SM/J mice.
Not available
S-EPMC3652381 | biostudies-literature
OtherGenetic Loci that Regulate Ectopic Calcification in Response to Knee Trauma in LG/J by SM/J Advanced Intercross Mice
Ectopic calcification in synovial tissues is devastating to diarthrodial joints. While some forms of synovial ectopic calcification have genetically simple basis, most cases manifest as complex traits with environmental and multigenic components. The location of causal loci or the physiological proc...
ORGANISM(S): Mus musculus 
2015-01-09 | GSE64793 | GEO
UnknownDigit regeneration is expedited in LG/J healer mice compared to SM/J non-healer mice.
Not available
S-EPMC11828864 | biostudies-literature
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