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TranscriptomicsCrosstalk between gene body DNA methylation, H3K9me3 and H3K36me3 chromatin marks and transcription [HuGene-1_0-st]
This is one of expressional parts of the study. These data were correlated to epigenetic marks and CG density of genes in analyzed cells. The whole study has a following summary: To elucidate possible roles of DNA methylation and chromatin marks in transcription, we performed epigenetic profiling of...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-26019 | biostudies-arrayexpress
TranscriptomicsUVB irradiation does not directly induce detectable changes of DNA methylation in human keratinocytes
Unprotected exposure to UVB radiation from the sun and the resulting DNA damage are thought to be responsible for physiological changes in the skin and for a variety of skin cancers, including basal cell and squamous cell carcinoma and malignant melanoma. Although the mutagenic effects of UVB have b...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-GEOD-42943 | biostudies-arrayexpress
TranscriptomicsWhole DNA methylome profiling in mice exposed to secondhand smoke
A large body of evidence has linked secondhand smoke (SHS) to lung cancer in nonsmokers. Yet, the underlying mechanisms of SHS carcinogenicity in nonsmokers' lung cancer remain elusive. Recently, we have demonstrated a genotoxic mode of action for SHS, based on the ability of this carcinogen to indu...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-41421 | biostudies-arrayexpress
TranscriptomicsGamma irradiation does not induce detectable changes in DNA methylation in exposed human cells
Ionizing radiation, released during accidents at nuclear power plants or after atomic bomb explosions, is a potentially serious health threat for the exposed human population. This type of high-energy radiation causes DNA damage including single- and double-strand breaks and induces chromosomal rear...
ORGANISM(S): Homo sapiens 
2012-11-29 | E-GEOD-39038 | biostudies-arrayexpress
TranscriptomicsThe tumor suppressor Rassf1a prevents mouse liver tumorigenesis and regulates levels of the oncogenic kinase Tbk1 and of beta tubulin gene expression in the liver
The tumor suppressor gene RASSF1A (Ras association domain family protein 1A) coding for a microtubule stabilizing protein is epigenetically silenced in most human cancers. As a binding partner of the kinases MST1 and MST2, the mammalian orthologues of the Drosophila Hippo kinase, RASSF1A is a potent...
ORGANISM(S): Mus musculus 
2016-05-31 | E-GEOD-73911 | biostudies-arrayexpress
TranscriptomicsFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress
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