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Patient-derived GBM stem-like cells (GSCs) were first cultured to form glioma spheroids and then co-cultured with the brain organoid (BO) derived from fetal rat brains for 72 hours. To investigate the metabolite produced by GBM under physiological conditions, , we used an in vitro co-culture model f...
2026-04-15 | MTBLS14187 | MetaboLights
Objective. B-cell chronic lymphocytic leukemia is a heterogeneous disease with a pronounced variation in the clinical course. With the purpose of identifying genes that could be related to disease progression, we have performed gene expression profiling on B-CLL patients with an indolent disease and...
ORGANISM(S): Homo sapiens 

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
Purpose: Zinc deficiency (ZnD) and iron deficiency (FeD), excess Zn (ZnE) and cadmium exposure (CdE) are major environmental problems for crop cultivation. Methods: Applying Tag-Seq technology to leaves of Brassica rapa grown under FeD, ZnD, ZnE or CdE conditions, with normal conditions as a control...
ORGANISM(S): Brassica rapa 
Brain organoids (BO) enabled the investigation of human corticogenesis in-vitro with an increasing range of protocols achieving its remarkable recapitulation. However, we lack a resource gathering fetal cortex-specific gene co-expression patterns and their behavior in BO. We complement the current k...
ORGANISM(S): Homo sapiens 
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