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MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
ProteomicsStructure-based discovery of a chemical probe targeting the Tudor domain of FMRP
Fragile X mental retardation protein (FMRP) is an RNA-binding protein whose loss of function is associated with neurodevelopmental disorders, including fragile X syndrome and autism, and whose aberrant overexpression has been linked to immune-related cancers. Here, we report XY6-1, a potent and sele...
ORGANISM(S): Homo sapiens (Human) 
2026-07-30 | PXD072708 | Pride
Tudor domain Fmrp Chemical probe 
TranscriptomicsGene expression profiles in human kidney cancer cells in response to FoxO1 or FoxO3 activation
The mammalian FoxO transcription factors - FoxO1, FoxO3, FoxO4 - function in the nucleus to direct transcription of specific gene targets governing cellular survival, proliferation, metabolism, differentiation and oxidative defense. Activation of PI3K by extracellular growth factors leads to AKT-med...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-23926 | biostudies-arrayexpress
ProteomicsMyocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-proteomic sequencing
Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression in...
ORGANISM(S): Mus Musculus 
2025-03-20 | PXD062097 |
ProteomicsMyocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-mass spectrometry
Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression in...
ORGANISM(S): Mus Musculus 
2025-03-20 | PXD062096 |
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