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TranscriptomicsFMRP-associated MOV10 facilitates and antagonizes miRNA-mediated regulation
The fragile X mental retardation protein FMRP is an RNA binding protein that regulates translation of its bound mRNAs through incompletely defined mechanisms. FMRP has been linked to the microRNA pathway and we show here that it is associated with MOV10, a putative helicase that is also associated w...
ORGANISM(S): Homo sapiens 
2014-11-20 | E-GEOD-50499 | biostudies-arrayexpress
TranscriptomicsFMR1 targets distinct mRNA sequence elements to regulate protein expression [Affymetrix]
Fragile-X Syndrome (FXS) is a multi-organ disease leading to mental retardation, macro-orchidism in males, and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASD). FXS is typically caused by the loss of FRAGILE...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-39504 | biostudies-arrayexpress
TranscriptomicsRole of FMRP in neurogenesis
Fragile X syndrome (FXS) is a rare disease but is the most common form of inherited intellectual disability and a leading cause of autism. FXS is due to the absence of the Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein mainly involved in translational control. Even if this molec...
ORGANISM(S): Mus musculus 
2016-07-04 | E-GEOD-71184 | biostudies-arrayexpress
TranscriptomicsOver-expression of truncated FMRP with 295 amino acid residues: HEK293T cells
We used microarrays to detail the global gene expression in stably transfected HEK 293T cells of the over-expression of truncated FMRP containing 295 amino acid residues, which were compared with control (stably transfected HEK 293T cells of empty lentiviral vector (pLEX-MCS). Stably transfected HEK...
ORGANISM(S): Homo sapiens 
2015-05-08 | E-GEOD-68668 | biostudies-arrayexpress
TranscriptomicsHITS-CLIP analysis of FMRP mRNA binding sites from P11-P25 mouse brain polysomes
FMRP loss-of-function causes Fragile X Syndrome (FXS) and autistic features. FMRP is a polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role in regulating neuronal translation, but there has been little consensus regarding either its RNA targets or mechanism of a...
ORGANISM(S): Mus musculus 
2013-03-15 | E-GEOD-45148 | biostudies-arrayexpress
TranscriptomicsFMR1 targets distinct mRNA sequence elements to regulate protein expression [PAR-CLIP]
Fragile-X Syndrome (FXS) is a multi-organ disease leading to mental retardation, macro-orchidism in males, and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASD). FXS is typically caused by the loss of FRAGILE...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-39682 | biostudies-arrayexpress
TranscriptomicsThe Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase in neurons
In this study, we sought to identify the mRNAs associated to FMRP protein in mouse cortical neuron using a cross linking immunoprecipitation and microarray (CLIP-microarray). The mRNAs crosslinked at 254 nm to FMRP in mouse cortical neurons cultured 8 days in vitro (8 DIV) were immunoprecipitated wi...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-51649 | biostudies-arrayexpress
GenomicsFMRP targets in human neurons
FMRP targets in human neurons
PRJNA914736 | ENA
ProteomicsTIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment
Chronic myeloid leukemia (CML) cells circulate between blood and bone marrow niche, representing different microenvironments. We studied the role of the two RNA binding proteins, T-cell-restricted intracellular antigen (TIAR) and the fragile X mental retardation protein (FMRP) in the regulation of p...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD032332 | Pride
Quancat Fmrp Chronic myeloid leukemia Tiar 
ProteomicsIntercepting IRE1 Kinase-FMRP Signaling Prevents Atherosclerosis Progression
Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is an RNA-binding protein (RBP) that controls translation of select mRNAs. We discovered that endoplasmic reticulum (ER) stress induces phosphorylation of FMRP on a site that is known to enh...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-02-15 | PXD030594 | Pride
Cholesterol homeostasis Translational regulation Kinase-substrate Atherosclerosis Efferocytosis 
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