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ORGANISM(S): Mus musculus 
Inflammation is a physiopathological process triggered by infection or tissue damage. Immune system initiates coordinated sequential steps in response to these danger signals. Once the threat has been contained inflammation has to be subsequently shut down. Inflammation resolution is initiated by the...
ORGANISM(S): Homo sapiens 
Broad-spectrum antibiotics disrupt homeostatic efferocytosis
Poor wound healing due to dysregulated tissue repair responses can exacerbate and prolong disease. Successful tissue repair is critically dependent on the timely clearance of apoptotic cells by macrophages in a process termed efferocytosis. Mechanisms and factors that link these two fundamental proc...
ORGANISM(S): Homo sapiens (Human) 
2023-12-12 | PXD038390 | Pride
Transcriptional analysis of efferocytosis in mouse skin wounds
Within the human body, billions of cells undergo apoptosis daily, and it is important that these cells are efficiently removed without causing an inflammatory response. This is mainly carried out by innate immune cells, such as macrophages, in a process referred to as efferocytosis. During efferocyt...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-09-04 | PXD072778 | Pride
Here, we show that neutrophils infected with the bacterial pathogen Porphyromonas gingivalis (Pg) are internalized alive by macrophages in a manner that bypasses all known efferocytic receptor-ligand interactions with highly inflammatory outcomes. Mechanistically, proteolytic cleavage of neutrophil ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD051073 | Pride
Broad-spectrum antibiotics disrupt homeostatic efferocytosis [bulk RNA-seq]
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