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ProteomicsHigh-throughput identification of FLT3 wild-type and mutant kinase substrate preferences and application to design of sensitive in vitro kinase assay substrates
Abnormalities in the FLT3 signaling pathway play an integral role in AML disease relapse and drug resistance. Developing new and specific FLT3 tyrosine kinase inhibitors for use in combination to induction therapy is an important step to reduce disease relapse and achieve clinical remission. To deve...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011478 | Pride
Kinase assay linked with phosphoproteomics Flt3 Acute myeloid leukemia Mass spectrometry Phosphoproteomics 
TranscriptomicsTranscription profiling of Arabidopsis reveals Flg22 regulates MAP kinase 6 interaction with an ethylene response factor substrate via ethylene
Despite their importance, plant MAP kinase targets are still poorly elucidated. Here, the specific in vivo interaction of an ethylene response factor (ERF104) with the Arabidopsis MAP kinase, MPK6, is shown by fluorescence resonance energy transfer. The interaction, which is lost within minutes afte...
ORGANISM(S): Arabidopsis thaliana 
2009-05-27 | E-GEOD-11807 | biostudies-arrayexpress
GenomicsPantothenate kinase 4 controls skeletal muscle substrate metabolism
Pantothenate kinase 4 controls skeletal muscle substrate metabolism
PRJNA1142866 | ENA
ProteomicsAutophosphorylation of the CK1 kinase domain regulates enzyme activity and substrate specificity
CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. Here, we describe a new mechanism of CK1 regulation conserved from yeast to human – autopho...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-07-20 | PXD026766 | Pride
Casein kinase 1 Ck1 S. pombe Substrate specificity Kinase regulation 
ProteomicsInterrogating kinase-substrate relationships with proximity labeling and phosphorylation enrichment
Kinases govern many cellular responses through the reversible transfer of a phosphate moiety to their substrates. However, pairing a substrate with a kinase is challenging. In proximity labeling experiments, proteins proximal to a target protein are marked by biotinylation, and mass spectrometry can...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD028150 | Pride
Kinases Apex Substrates Mapk1 Pka Proximity labeling 
ProteomicsSubstrate phosphorylation of protein microarray by leucine-rich repeat kinase 2
Numerous leucine-rich repeat kinase 2 mutations identified throughout the protein are associated with Parkinson disease, however the activating G2019S kinase domain mutation is currently regarded as the most common cause of familial and sporadic forms of this disorder. Despite studies demonstrating...
ORGANISM(S): Homo sapiens 
2012-07-13 | E-GEOD-30496 | biostudies-arrayexpress
ProteomicsPhosphosecretome profiling and kinase-substrate interaction screening reveal key extracellular c-Src-regulated pathways
Secreted protein kinases are responsible for the phosphorylation of a vast number of extracellular phosphoproteins. The tyrosine kinase c-Src is secreted through the vesicular trafficking pathway, however, mechanistic insights into extracellular substrate specificity and potential therapeutic opport...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-05-30 | PXD036069 | Pride
Post translational modification The tissue inhibitors of metalloproteinases Pxxp motif Src tyrosine kinase Timps Tumor growth inhibition Phosphoproteomic Blocking antibodies Secretome 
UnknownModular composition predicts kinase/substrate interactions.
Not available
S-EPMC2912303 | biostudies-literature
UnknownDistinct structural mechanisms determine substrate affinity and kinase activity of protein kinase Cα.
Not available
S-EPMC5625059 | biostudies-literature
UnknownKSIMC: Predicting Kinase⁻Substrate Interactions Based on Matrix Completion.
Not available
S-EPMC6358935 | biostudies-literature
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