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TranscriptomicsAberrant ERK signaling causes resistance to EGFR kinase inhibitors
The clinical efficacy of EGFR kinase inhibitors is limited by the development of drug resistance. The irreversible EGFR kinase inhibitor WZ4002 is effective against the most common mechanism of drug resistance mediated by the EGFR T790M mutation. Here we show that in multiple complementary models ha...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-37699 | biostudies-arrayexpress
GenomicsMAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor (RNA-Seq)
MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor (RNA-Seq)
PRJNA979199 | ENA
GenomicsMAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor (ChIP-Seq)
MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor (ChIP-Seq)
PRJNA979198 | ENA
GenomicsMAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor (ChIP-Seq)
Background Mitogen-activated protein kinase 1 (MAPK1) has independent functions of phosphorylating histones as a kinase and directly binding the promoter regions of genes to regulate gene expression as a transcription factor. Previous studies identified elevated expression of MAPK1 in human gastric ...
ORGANISM(S): Homo sapiens 
2023-10-06 | GSE234022 | GEO
TranscriptomicsMAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor (RNA-Seq)
Background Mitogen-activated protein kinase 1 (MAPK1) has independent functions of phosphorylating histones as a kinase and directly binding the promoter regions of genes to regulate gene expression as a transcription factor. Previous studies identified elevated expression of MAPK1 in human gastric ...
ORGANISM(S): Homo sapiens 
2023-10-06 | GSE234020 | GEO
UnknownMechanosensitive Conformation of Vinculin Regulates Its Binding to MAPK1.
Not available
S-EPMC5425409 | biostudies-literature
UnknownFGF21-MAPK1 Imbalance Disrupts Hepatic Lipid Metabolism in Dairy Cow Ketosis.
Not available
S-EPMC12470934 | biostudies-literature
ProteomicsInterrogating kinase-substrate relationships with proximity labeling and phosphorylation enrichment
Kinases govern many cellular responses through the reversible transfer of a phosphate moiety to their substrates. However, pairing a substrate with a kinase is challenging. In proximity labeling experiments, proteins proximal to a target protein are marked by biotinylation, and mass spectrometry can...
ORGANISM(S): Homo sapiens (Human) 
2022-03-11 | PXD028150 | Pride
Kinases Apex Substrates Mapk1 Pka Proximity labeling 
GenomicsMAPK1 mediates C/EBPβ phosphorylation to promote maturation and inhibit EMT process in hESC-derived hepatocytes [RNA-seq]
MAPK1 mediates C/EBPβ phosphorylation to promote maturation and inhibit EMT process in hESC-derived hepatocytes [RNA-seq]
PRJNA1301960 | ENA
GenomicsMAPK1 mediates C/EBPβ phosphorylation to promote maturation and inhibit EMT process in hESC-derived hepatocytes [CUT&Tag]
MAPK1 mediates C/EBPβ phosphorylation to promote maturation and inhibit EMT process in hESC-derived hepatocytes [CUT&Tag]
PRJNA1301964 | ENA
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