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TranscriptomicsTIAR represses c-Myc biosynthesis following ultraviolet light irradiation
RNA was isolated from material that had been subjected to immunoprecipitation (IP) from RKO cells that were either left untreated or irradiated with 20 J/m2 UVC and collected 1h later; IP assays were carried out using either an antibody recognizing RNA-binding protein TIAR, or using a control IgG1 a...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1433 | biostudies-arrayexpress
TranscriptomicsThe permanent reduction of TIA proteins molds expression transcriptome in HeLa cells
This study provides, for the first time, TIA1 and TIAR linked-transcriptomic analysis by using RNA-Seq next-generation sequencing technology. Illumina RNA-Seq was used to survey transcriptome profiles from permanent TIA1- and TIAR-(shRNA-mediated) deficient HeLa cells. Analysis of the transcriptomes...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-46516 | biostudies-arrayexpress
ProteomicsTIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment
Chronic myeloid leukemia (CML) cells circulate between blood and bone marrow niche, representing different microenvironments. We studied the role of the two RNA binding proteins, T-cell-restricted intracellular antigen (TIAR) and the fragile X mental retardation protein (FMRP) in the regulation of p...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD032332 | Pride
Quancat Fmrp Chronic myeloid leukemia Tiar 
TranscriptomicsGenome-wide analysis of TIAR RNA ligands in mouse macrophages before and after LPS stimulation
TIA-1 related protein (TIAR) is a RNA-binding protein involved in several steps of gene expression such RNA splicing and translation. TIAR contains three RNA recognition motifs (RRMs) allowing its interaction with specific sequences localized in the untranslated regions (UTRs) of several mRNAs. In ...
ORGANISM(S): Mus musculus 
2016-02-05 | E-GEOD-77577 | biostudies-arrayexpress
TranscriptomicsT-cell intracellular antigen (TIA) proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy
Background: Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1-related/like protein (TIAR/TIAL1) show high rates of embryonic lethality, suggesting a relevant role for these proteins during embryonic development. However, intrinsic molecular and cellular consequences of either TIA1 or...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-43077 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of TIA-proteins in human HeLa cells
Analysis of gene expression profiles during the course of both TIA-1 and TIAR expression suppression in HeLa cells
ORGANISM(S): Homo sapiens 
2009-02-27 | E-MTAB-93 | biostudies-arrayexpress
UnknownTranslational repression by RNA-binding protein TIAR.
Not available
S-EPMC1430315 | biostudies-literature
UnknownImpaired embryonic development in mice overexpressing the RNA-binding protein TIAR.
Not available
S-EPMC2893167 | biostudies-literature
UnknownInhibition of Axon Regeneration by Liquid-like TIAR-2 Granules.
Not available
S-EPMC6813885 | biostudies-literature
GenomicsPHAROH lncRNA regulates c-Myc translation in hepatocellular carcinoma via sequestering TIAR
PHAROH lncRNA regulates c-Myc translation in hepatocellular carcinoma via sequestering TIAR
PRJNA704277 | ENA
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