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ProteomicsPlasma Proteomics in Patients with Age-related Sarcopenia
Data-independent acquisition-based proteomics was performed on plasma samples from 60 hospitalized participants, 30 with age-related sarcopenia and 30 without. In the data, label "A" represents "sarcopenia", and "B" represents "non-sarcopenia". This study was approved by the ethics committee of hosp...
ORGANISM(S): Homo Sapiens 
2024-07-07 | PXD053735 |
ProteomicsDiscovery of 180055 as a PROTAC degrader for Treating Cancers
PARP1 is an abundant nuclear protein that is involved in a number of biological processes linked to cellular stress responses. PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (PARP1 catalytic inhibition and PARP1 trapping). In this work we discovered a PROTAC degrader of PA...
ORGANISM(S): Homo Sapiens 
2023-05-18 | PXD042311 |
ProteomicsFER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer
Tyrosine phosphorylation, orchestrated by tyrosine kinases and phosphatases, modulates a multi-layered signaling network in a time and space dependent manner. Dysregulation of this post-translational modification is inevitably associated with pathological diseases. Our previous work has demonstrated...
ORGANISM(S): Homo Sapiens 
2020-10-19 | PXD022084 |
UnknownFine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
Not available
S-EPMC3036586 | biostudies-literature
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