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UnknownFusobacterium nucleatum-reprogrammed adipocytes promote tumor cisplatin resistance through the CCL2-CCR2 axis in the necrotic metastatic neck nodes of head and neck carcinoma.
Not available
S-EPMC12750780 | biostudies-literature
ProteomicsTemporal proteomics of p97/VCP inhibition
To facilitate the development of p97 inhibitors as potential therapeutic agents and help define their clinical application, it is necessary to dissect the mechanism of action (MOA) of p97 inhibitors and compare them with proteasome inhibitors. Moreover, identifying specific cellular markers is criti...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD025167 | Pride
Proteasome inhibitor Hct116 P97 inhibitor Proteomic 
ProteomicsTemporal proteomics of p97/VCP inhibition
To facilitate the development of p97 inhibitors as potential therapeutic agents and help define their clinical application, it is necessary to dissect the mechanism of action (MOA) of p97 inhibitors and compare them with proteasome inhibitors. Moreover, identifying specific cellular markers is criti...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD025094 | Pride
Proteasome inhibitor Hct116 P97 inhibitor Proteomic 
ProteomicsProteomic Profiling Identifies Novel Diagnostic Biomarkers and Molecular subtypes for Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
Mucinous tubular and spindle cell carcinoma (MTSCC) is a relatively rare renal epithelial neoplasm resembling type 1 papillary renal cell carcinoma (PRCC) morphologically and immunohistochemically. The accurate diagnosis of MTSCC remains a challenge. Here, by using proteomic profiling, we characteri...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD027972 | Pride
Mucinous tubular and spindle cell carcinoma Immunohistochemistry Proteomic Kidney 
TranscriptomicsHistone 4 Lys-20 Mono-Methylation by SET8 Mediates Wnt Target Gene Activation
Histone methylation has an important role in transcriptional regulation. However, unlike H3K4 and H3K9 methylation, the role of H4K20 mono-methylation (H4K20me-1) in transcriptional regulation remains unclear. Here we show that Wnt3a specifically stimulates H4K20 mono-methylation at TBE (TCF-binding...
ORGANISM(S): Homo sapiens 
2010-12-29 | E-GEOD-24708 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse prostate over-expressing the Notch1 intracellular domain.
Molecular signaling that regulates differentiation, survival and proliferation of the prostate luminal epithelial cells has not been thoroughly understood. Herein, we show that increased canonical Notch1 activity suppresses terminal differentiation of prostate luminal epithelial cells but is insuffi...
ORGANISM(S): Mus musculus 
2014-08-07 | E-GEOD-53036 | biostudies-arrayexpress
UnknownBiotic interchange between the Indian subcontinent and mainland Asia through time.
Not available
S-EPMC4932189 | biostudies-literature
ProteomicsUnveiling Biomarkers of Telitacicept’s Efficacy in SLE Treatment Through Proteomics
Our study is highly relevant to the fields of Medical Bioinformatics and Personalised Medicine, as it employs high-throughput omics technologies and bioinformatics analyses to uncover personalized biomarkers predictive of treatment response, thereby paving the way for tailored therapeutic strategi...
ORGANISM(S): Homo Sapiens 
2026-02-02 | PXD073923 |
UnknownThe transcription factor complex CmAP3-CmPI-CmUIF1 modulates carotenoid metabolism by directly regulating carotenogenic gene CmCCD4a-2 in chrysanthemum.
Not available
S-EPMC9125392 | biostudies-literature
TranscriptomicsInteraction transcriptome of host wheat and hemibiotrophic fungal pathogen Septoria tritici during disease transition Transcriptome or Gene expression
To gain comprehensive information on the molecular and physiological bases during particular stages of the interaction between wheat and S. tritici, we explored the complexity of transcriptional reprogramming of both host and pathogen at three time points (day 4, 10 and 13) by RNA-Seq analysis. The ...
ORGANISM(S): Triticum aestivum 
2013-05-30 | E-MTAB-4470 | biostudies-arrayexpress
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