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ProteomicsMDA5 signaling in splenic B cells from imiquimod-induced lupus mouse model with proteomics study
Abstract Introduction Several environmental stimuli may influence lupus, especially viral infection. We utilize an imiquimod-induced lupus mouse model focusing on TLR7 pathway and use proteomics analysis to figure out the specific pathway related to viral infection and its related protein expression...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034855 | Pride
Mouse model B cell Imiquimod (imq) Proteomics Lupus Mda5 
UnknownA polymeric prodrug of 5-fluorouracil-1-acetic acid using a multi-hydroxyl polyethylene glycol derivative as the drug carrier.
Not available
S-EPMC4229301 | biostudies-literature
UnknownTargeting PRPK Function Blocks Colon Cancer Metastasis.
Not available
S-EPMC5940014 | biostudies-literature
ProteomicsProteomic and metabolomic studies of transplanted gastric epithelial cell mitochondria in reducing gastric cancer cell malignancy
Mitochondria exhibit diverse effects on cellular responses. Mitochondrial transplantation from gastric epithelial cells GES-1 to gastric cancer cells AGS reduces cancer malignancy was previously reported. We employed proteomic and metabolomic analyses to elucidate underlying mechanisms. iTRAQ/TMT-ba...
ORGANISM(S): Homo sapiens (Human) 
2026-05-18 | PXD061705 | Pride
Metabolomics Mitochondrial transplantation Proteomics Gastric cancer Pyruvate 
ProteomicsCombining proximity labeling and crosslinking mass spectrometry for proteomic dissection of nuclear envelope interactome
Analysis of LAP1 interactome in HEK293T cells using proximity labeling or proximity labeling combined with crosslinking methods.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-11-20 | MSV000084606 | MassIVE
UnknownThe impact of logistic environment and spatial spillover on agricultural economic growth: An empirical study based on east, central and west China.
Not available
S-EPMC10370687 | biostudies-literature
TranscriptomicsGene expression profiling in BCR/ABL-expressing LSCs and BCR/ABL-expressing Hif1a-/-LSCs
Using a mouse model of chronic myelogenous leukemia (CML), here we report that HIF1M-NM-1 plays a crucial role in survival maintenance of leukemia stem cells (LSCs). Deletion of HIF1M-NM-1 impairs the propagation of CML through impairing cell cycle progression and inducing apoptosis of LSCs. Deletio...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-35111 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in wild type and Hif1a-deficient normal and leukemia stem cells
This SuperSeries is composed of the following subset Series: GSE35110: Gene expression profiling in WT and Hif1a-/- HSCs GSE35111: Gene expression profiling in BCR/ABL expressing LSCs and BCR/ABL expressing Hif1a-/-LSCs Refer to individual Series
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-35183 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in BCR-ABL expressing LSCs and BCR-ABL-BLK expressing LSCs
Using BCR-ABL-induced chronic myeloid leukemia (CML) as a disease model for leukemia stem cells (LSCs), we showed that BCR-ABL down-regulates the B lymphoid kinase (Blk) gene in leukemia stem cells in CML mice and that Blk functions as a tumor suppressor in LSCs and suppresses LSC function. Inhibiti...
ORGANISM(S): Mus musculus 
2012-07-05 | E-GEOD-36096 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in BCR/ABL expressing LSCs and BCR/ABL expressing Alox5-/-LSCs
We previously demonstrated that Alox5 deficiency impairs the function of LSCs and prevents the initiation of BCR-ABL-induced CML. To identify the pathways in which Alox5 gene regulates function of LSCs, we performed a comparative DNA microarray analysis using total RNA isolated from non-BCR-ABL-expr...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29347 | biostudies-arrayexpress
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