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ProteomicsMitochondrial glutamine import sustains mitochondrial translation independent of glutaminolysis in cancer
Oxidative phosphorylation (OXPHOS) fulfills energy metabolism and biosynthesis through tricarboxylic acid (TCA) cycle and an intact electron transport chain (ETC). Mitochondrial glutamine import (MGI) replenishes TCA cycle through glutaminolysis, but its broader roles in cancer remains unclear. Here...
ORGANISM(S): Homo Sapiens 
PXD069373 |
ProteomicsSLC6A6 imports taurine into mitochondria to sustain mitochondrial translation and tumour growth
Taurine plays a crucial role in mitochondrial tRNA modification essential for mitochondrial translation. Mammalian cells obtain taurine through plasma membrane transporter SLC6A6-mediated uptake exogenously or cytosolic biosynthesis. However, it remains unclear how taurine enters mitochondria and im...
ORGANISM(S): Homo Sapiens 
2025-11-29 | PXD071408 |
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_untargeted metabolites_flux_FAO

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12738 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_lipid

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12741 | MetaboLights
ProteomicsGlycan Markers of Human Stem Cells Assigned with Beam Search Arrays
Glycan antigens recognized by monoclonal antibodies have served as stem cell markers. To understand regulation of their biosynthesis and their roles in stem cell behavior precise assignments are required. We have applied state-of-the-art glycan array technologies to compare the glycans bound by five...
ORGANISM(S): Cellular Organisms 
2019-06-18 | PXD013972 | JPOST Repository
ProteomicsChronic Stress Induced and Tumor Derived SP1+ exosomes Polarizing IL-1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer
We collected tumor-derived exosomes of 4T1 tumor-bearing mice in the control group and the stress group.
ORGANISM(S): Mus Musculus 
2023-12-26 | PXD048125 |
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