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ProteomicsQuantitative proteomics analysis of acute myeloid leukemia cells after NAT10 knockdown
RNA modification represents an important post-transcriptional regulatory mechanism in acute myeloid leukemia (AML). Given that the critical function of ac4C in control RNA translation, we sought to investigate the global impact of ac4C on protein expression. To this end, we conducted tandem mass tag...
ORGANISM(S): Homo sapiens (Human) 
2024-08-26 | PXD055119 | Pride
Rna acetylation (ac4c)  acute myeloid leukemia  leukemic stem cells (lscs)  metabolic reprogramming  serine synthesis pathway  epigenetic inhibitor 
TranscriptomicsALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to abnormally enhance their interaction with SMN and reduce interaction with U1-snRN...
ORGANISM(S): Homo sapiens 
2015-02-10 | E-GEOD-64078 | biostudies-arrayexpress
ProteomicsHDAC8_SAHA_PCI-34051_HDX-MS_Luo
This dataset contains the HDX-MS raw mass spectra data in the article 'Integrating native MS, HDX-MS, and MD simulations to uncover the dynamic inhibition mechanism and distant structural changes of PCI-34051 on HDAC8'.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-12 | MSV000096388 | MassIVE
UnknownRibosomal protein L27 contributes to virulence and maduramicin resistance in Eimeria tenella.
Not available
S-EPMC12509730 | biostudies-literature
UnknownStructure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs
Not available
EMPIAR-11912 | biostudies-other
UnknownStructure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304
Not available
EMPIAR-11921 | biostudies-other
UnknownStructure of human constitutive 20S proteasome complexed with the inhibitor TDI-8304
Not available
EMPIAR-11842 | biostudies-other
UnknownStructure of the C-terminal protease CtpA-LbcA complex of Pseudomonas aeruginosa
Not available
EMPIAR-12200 | biostudies-other
UnknownStructure of Mycobacterium tuberculosis pyruvate dehydrogenase complex E2p core subunit DlaT
Not available
EMPIAR-13380 | biostudies-other
ProteomicsSpatiotemporal dog brain proteome
The complexity and low accessibility of the human brain make it challenging to understand its development, function, and disorders. Brain diseases including neurodegenerative disease and psychiatric diseases incur huge medical and social burdens without effective treatments. While mouse has substant...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-08-12 | PXD033420 | Pride
Brain Multiple regions Proteome Canine 
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