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TranscriptomicsCardiac muscle ring finger-1 increases susceptibility to heart failure by inhibiting creatine kinase activity in vivo
Muscle ring finger-1 (MuRF1) is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates, and hetero-dimerizes with MuRF1. Mice lacking either MuRF1 or MuRF2 are phenotypica...
ORGANISM(S): Mus musculus 
2009-06-03 | E-GEOD-11661 | biostudies-arrayexpress
MetabolomicsPTER is an N-acetyltaurine hydrolase that regulates feeding and obesity

Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans1-3. In endogenous taurine metabolism, dedicated enzymes are involved in biosynthesis of taurine from cysteine as well as the downstream metabolism of secondary taurine metabolites4,5. One such ta...

2024-09-11 | MTBLS10408 | MetaboLights
TranscriptomicsMuRF1 regulation of Fenofibrate’s induction of spontaneous cardiac hypertrophy in vivo.
MuRF1 -/- w/ Fenofibrate treatment leads to the reduction of proteolytic and fibrolytic enzymes, increasing hypertrophy Four strain-matched groups of 3-8 week old mice were investigated: 1) MuRF1 -/- Fenofibrate feed; 2) MuRF1 -/- chow feed; 3) MuRF1 +/+ Fenofibrate feed; 4) MuRF1 +/+ chow feed at...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-68480 | biostudies-arrayexpress
TranscriptomicsExpression data from human skin exposed to solar-simulated radiation with or without sunscreen
Despite widespread use of sunscreens that minimize erythema by blocking ultraviolet B (UVB) radiation, incidence rates of melanoma continue to rise. In considering this disparity between intervention and disease prevalence, we investigated the in vivo transcriptome of human skin treated with sunscr...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-22083 | biostudies-arrayexpress
TranscriptomicsThe transcriptional programme of Salmonella Typhimurium reveals a key role for tryptophan metabolism in biofilms
Background: Biofilm formation by Salmonella species enhances the capacity of these pathogenic bacteria to survive stresses that are commonly encountered within food processing and during host infection. The persistence of Salmonella within the food chain has become a major health concern, as biofilm...
ORGANISM(S): Salmonella enterica 
2010-05-18 | E-GEOD-17246 | biostudies-arrayexpress
GenomicsFOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function
FOXA1 is a FKHD family protein that translates epigenetic signatures at target enhancers to lineage-specific transcription and differentiation. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of this epigenetic signat...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73363 | biostudies-arrayexpress
ProteomicsThe plasma proteome of Rufous-collared sparrows (Zonotrichia capensis) from valleys of the Atacama Desert (Chile)
The plasma proteome of sparrows from the Atacama desert was identified using bottom up proteomics by online nanoLC tandem mass spectrometry. Seasonal and geographic effects on the plasma proteome were investigated. All experiments and sample collections were performed by the team of Dr. Paulina Gonz...
ORGANISM(S): Zonotrichia Capensis (ncbitaxon:44391) 
2018-04-26 | MSV000082313 | MassIVE
ProteomicsThe kidney proteome of the rufous-collared sparrow (Andean sparrow, Zonotrichia capensis) from Chile
Kidney proteomes of Rufous-collared sparrows from two different areas of the Atacama desert (Chile) were identified and compared by bottom-up proteomics utilizing nanoUPLC coupled online to tandem mass spectrometry. All experiments and sample collections were performed by the team of Dr. Paulina Gon...
ORGANISM(S): Zonotrichia Capensis (ncbitaxon:44391) 
2018-04-26 | MSV000082314 | MassIVE
ProteomicsTracheal aspirate proteome from hospitalized patients infected with SARS-CoV-2
Tracheal aspirate was collected from intubated patients with SARS-CoV-2 infections or for reasons not related to COVID-19 (controls). The proteins were extracted using the MPLEx method. Proteins were digested with trypsin and analyzed by LC-MS/MS on a Thermo Q Exactive HF-X. Data was searched with M...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-06 | MSV000089614 | MassIVE
UnknownRetrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Not available
S-EPMC7505971 | biostudies-literature
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