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UnknownSingle-cell transcriptome reveals cellular heterogeneity and lineage-specific regulatory changes of fibroblasts in post-traumatic urethral stricture.
Not available
S-EPMC9898624 | biostudies-literature
ProteomicsRHBDL2 Drives Lipid Metabolic Reprogramming in Osteosarcoma via USP3-Mediated Deubiquitination of PPT1
Osteosarcoma (OS), a highly malignant bone tumor, is characterized by rapid progression and poor prognosis, with lipid metabolic reprogramming playing a crucial role in its pathogenesis. This study investigates the role of RHBDL2 in OS progression and its therapeutic potential. We demonstrate that R...
ORGANISM(S): Homo Sapiens 
2025-03-31 | PXD062405 |
MetabolomicsThe Manchurian Walnut Genome: Insights into Juglone and Lipid Biosynthesis

BACKGROUND: Manchurian walnut (Juglans mandshurica Maxim.) is a tree with multiple industrial uses and medicinal properties in the Juglandaceae family (walnuts and hickories). J. mandshurica produces juglone, which is a toxic allelopathic agent and has potential utilization value...

2022-05-18 | MTBLS3657 | MetaboLights
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
ProteomicsIdentification of FgSreA interactor
Affinity capture of FgSreA, reveal the molecular mechanisms of adapting excess iron mediated by FgSreA during infection in Fusarium graminearum
ORGANISM(S): Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) 
2024-01-26 | PXD035434 | Pride
Gfp 
UnknownDynamic chromatin landscape encodes programs for perinatal transition of cardiomyocytes.
Not available
S-EPMC9849264 | biostudies-literature
ProteomicsThe therapeutic mechanism of Dengzhanxixin injection on middle cerebral artery occlusion rats based on proteomics
To explore the therapeutic mechanism, we carried out an Dengzhanxixin injection experiment with a focal brain ischemic deficit rat model and explore the target proteins using TMT-based proteomics. Method are shown as follow: 1. Animals and Grouping: The animal experiments were conducted under the di...
ORGANISM(S): Rattus Norvegicus 
2021-06-25 | PXD026918 |
ProteomicsQuantitative proteomic analysis reveals novel function of DDRGK1 in osteosarcoma
DDRGK1 is identified as a target of ufymaltion, while its function in tumor is still largely unknown and even controversial according to recent study. To invesgate the role of DDRGK1 in osteosarcoma, DDRGK1 gene was knockout in 143B cells by CRISPR/cas9, and recombinant DDRGK1 protein was added in t...
ORGANISM(S): Homo Sapiens 
2022-07-21 | PXD035473 |
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