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ProteomicsDual-Optimized Surface Hydrophobicity and Rigidity Determines Protein Corona Absorption and Composition on Orally Delivered Nanoparticles Treating Colitis
Disease-specific protein corona adsorbed on nanocarriers critically determines their in vivo delivery efficiency. Given that macrophages can orchestrate inflammation resolution and mucosa repair, they are regarded as promising therapeutic targets in colitis. Here, we reveal that by altering the phys...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-21 | PXD071199 | Pride
Colitis Rigidity Hydrophobicity Oral Disease-specific protein corona 
ProteomicsDual-Optimized Surface Hydrophobicity and Rigidity Determines Protein Corona Absorption and Composition on Orally Delivered Nanoparticles Treating Colitis
Disease-specific protein corona adsorbed on nanocarriers critically determines their in vivo delivery efficiency. Given that macrophages can orchestrate inflammation resolution and mucosa repair, they are regarded as promising therapeutic targets in colitis. Here, we reveal that by altering the phys...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-21 | PXD071116 | Pride
Colitis Rigidity Hydrophobicity Oral Disease-specific protein corona 
ProteomicsProlyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer
Protein hydroxylation extensively regulates cellular signaling by affecting protein stability, protein-protein interaction and protein activity, and its dysregulation contributes to the pathogenesis of various diseases including cancers. However, because of the transient nature of the enzyme-substra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-02 | MSV000086231 | MassIVE
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