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MetabolomicsGut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy
Numerous studies found intestinal microbiota alterations which are thought to affect the development of various diseases through the production of gut-derived metabolites. However, the specific metabolites and their pathophysiological contribution to cardiac hypertrophy or heart failure progression ...
2021-12-08 | MTBLS3174 | MetaboLights
TranscriptomicsDynamic Expression of Imprinted Genes Associates with Maternally Controlled Nutrient Allocation during Maize Endosperm Development
In angiosperms, the endosperm provides nutrients for embryogenesis or seed germination and is the primary tissue where gene imprinting occurs. To map the imprintome of the early developing endosperm in maize, we performed high-throughput transcriptome sequencing of the kernels at 0, 3, 5 days after ...
ORGANISM(S): Zea mays 
2013-06-29 | E-GEOD-48425 | biostudies-arrayexpress
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsC1QBP mitochondrial interactome
The study of protein-protein interactions is an essential process to understand the biological functions of proteins and the underlying mechanisms. Co-immunoprecipitation coupled with mass spectrometry (CoIP-MS) is one of the most extensively used high-throughput techniques to discover novel protein...
ORGANISM(S): Homo Sapiens 
2015-11-04 | MSV000079369 | MassIVE
MetabolomicsIntegrated Multi-omics Analysis Identifies Diagnostic Biomarkers for Acute Coronary Syndrome in Type 2 Diabetes Mellitus Patients

Biomarkers for the early identification of acute coronary syndrome (ACS) risk remain inadequately investigated, particularly in patients with type 2 diabetes mellitus (T2DM), for whom timely clinical intervention may substantially enhance prognostic outcomes. The gut microbiota and serum metaboli...

2026-03-19 | MTBLS14087 | MetaboLights
ProteomicsProtemic analysis of differential sperm freezability in Mediterranean buffalo
Our study provides an understanding of proteins differences in differential freezability sperm which would ultimately helpful to depict the sperm freezability mechanism of Mediterranean buffalo.
ORGANISM(S): Bubalus Bubalis 
2022-06-06 | PXD034388 |
Proteomicslysine succinylation files of different freezability Mediterranean buffalo sperms.
For the first time this study provides lysine succinylation files of different freezability Mediterranean buffalo sperms.
ORGANISM(S): Bubalus Bubalis 
2021-11-29 | PXD030051 |
ProteomicsA protein-centric glycoproteomic strategy identifies site-specific glycans as robust diagnostic markers for hepatocellular carcinoma
In this study, we achieved the quantitative glycoproteomics analysis of a large cohort of clinical specimens including 100 Hepatocellular carcinoma (HCC) and 100 healthy control human serums by using an integrated platform.
ORGANISM(S): Homo Sapiens (human) 
2026-06-26 | PXD065283 | JPOST Repository
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
ProteomicsRNF25-Mediated NF-κB Activation Drives Anti-Apoptosis and Therapy Resistance in Cancer
Dysregulation of the NF-κB pathway is frequently observed in cancers, where it contributes to therapy resistance by inhibiting apoptosis. Mass spectrometry (MS)-based proteomics were employed to identify factors associated with the anti-apoptotic process. We identify RNF25, an E3 ubiquitin ligase, a...
ORGANISM(S): Homo Sapiens 
2025-03-05 | PXD061521 |
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