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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsNicotinamide N-Methyltransferase drives fibroblast activation and skin fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is characterized by progressive skin and organ fibrosis driven by persistently activated fibroblasts, however, the mechanisms of dermal fibroblast (DF) activation remain unclear. Nicotinamide N-methyltransferase (NNMT) has been linked to fibrosis in other diseases, but its r...
ORGANISM(S): Homo sapiens 
2026-10-20 | E-MTAB-17207 | biostudies-arrayexpress
TranscriptomicsNicotinamide N-Methyltransferase drives fibroblast activation and skin fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is characterized by progressive skin and organ fibrosis driven by persistently activated fibroblasts, however, the mechanisms of dermal fibroblast (DF) activation remain unclear. Nicotinamide N-methyltransferase (NNMT) has been linked to fibrosis in other diseases, but its r...
ORGANISM(S): Homo sapiens 
2026-10-20 | E-MTAB-17206 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in mutants of Arabidopsis FAX1 compared to wild type
DNA microarray analysis (Affymetrix ATH1 GeneChip) on mutant lines of the gene At-FAX1 (At3g57280) in Arabidopsis thaliana was performed as described in Li et al. (2015). In total we analyzed the following comparisons: (A) flowers: fax1 knockout (n = 5) versus wild type (n = 5); (B) flowers: FAX1 ov...
ORGANISM(S): Arabidopsis thaliana 
2015-02-04 | E-MTAB-3090 | biostudies-arrayexpress
ProteomicsN-Glycosylation profiling in rice
As a ubiquitous and essential posttranslational modification occurred in both plants and animals, protein N-linked glycosylation regulates various important biological processes. Unlike the well studied animal N-glycoproteomes, the landscape of rice N-glycoproteome remains largely unexplored. Here, ...
ORGANISM(S): Oryza sativa (Rice) 
2025-05-07 | PXD054828 | Pride
N-glycosylation Rice 
TranscriptomicsTranscription profiling of rat mammary tumors induced by N-methyl-N-nitrosurea (NMU) and normal mammary gland
Rat mammary tumors induced by N-methyl-N-nitrosurea (NMU) and normal mammary gland
ORGANISM(S): Rattus norvegicus 
2007-09-22 | E-GEOD-1872 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
TranscriptomicsGlobal Changes following N-deprivation in Chlamydomonas
This SuperSeries is composed of the following subset Series: GSE24365: Global Changes following N-deprivation in Chlamydomonas: Illumina sequencing GSE24366: Global Changes following N-deprivation in Chlamydomonas: 454 sequencing Refer to individual Series
ORGANISM(S): Chlamydomonas reinhardtii 
2010-09-24 | E-GEOD-24367 | biostudies-arrayexpress
ProteomicsN-glycoproteome profiling of rice
Metabolic glycan labeling (MGL) is a technique that utilizes bioorthogonal chemical reporters to investigate protein glycosylation. While this method has been widely used for glycoproteomic profiling in animals, its application in N-glycoproteomic research in crops remains limited and requires furth...
ORGANISM(S): Oryza sativa (Rice) 
2025-05-07 | PXD056001 | Pride
Metabolic glycan labeling (mgl) N-glycosylation Rice 
TranscriptomicsGlobal Changes following N-deprivation in Chlamydomonas: 454 sequencing
Chlamydomonas reinhardtii forms lipid droplets rich in triacylglycerols when nutrient-deprived. To begin studying the mechanisms underlying this process, N-deprivation was used to induce triacylglycerol accumulation and changes in developmental programs such as gametogenesis. Comparative global anal...
ORGANISM(S): Chlamydomonas reinhardtii 
2010-09-24 | E-GEOD-24366 | biostudies-arrayexpress
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