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TranscriptomicsInducing pluripotency from mouse somatic cells by small-molecule compounds [RNA-Seq]
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource for regenerative medicine. However, genetic manipulation and difficult-to-manufacture strategies used in reprogramming limit their clinical applications. Here, we show pluripotency can be induced from mous...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-48252 | biostudies-arrayexpress
UnknownRemoving batch effects from purified plasma cell gene expression microarrays with modified ComBat.
Not available
S-EPMC4355992 | biostudies-literature
ProteomicsThe new landscape of differentially expression proteins in placenta tissues of gestational diabetes based on iTRAQ proteomics
Proteomics screening of the DEPs of the normal and GDM maternal placentas was conducted by using isobaric tags for relative and absolute quantitation (iTRAQ). The bioinformatics analysis was performed on DEPs, and parallel reaction monitoring (PRM) was used to verify the DEPs. Sixty-eight DEPs in G...
ORGANISM(S): Homo Sapiens 
PXD033280 |
TranscriptomicsInducing pluripotency from mouse somatic cells by small-molecule compounds [Phalanx Mouse OneArray]
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource for regenerative medicine. However, genetic manipulation and difficult-to-manufacture strategies used in reprogramming limit their clinical applications. Here, we show pluripotency can be induced from mous...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-48201 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3T3-MEFs derived from wild-type and SMRT RID mutants
SMRT (silencing mediator of retinoid and thyroid hormone receptors) is recruited by numerous transcription factors to mediate lineage and signal dependent transcriptional repression. We generated a knock-in mutation in the receptor interaction domain (RID) of SMRT (SMRTmRID) that solely disrupts it...
ORGANISM(S): Mus musculus 
2009-01-18 | E-GEOD-13143 | biostudies-arrayexpress
TranscriptomicsGeneration of murine stem cells by small molecule
Transcriptional profiling of stem cells and parental cells Two samples were analyzed: PEG cells and parental cells. Each sample have three replicates.
ORGANISM(S): Mus musculus 
2015-05-20 | E-GEOD-47102 | biostudies-arrayexpress
ProteomicsProteomic landscape of serum exosomes to identify potential therapeutic targets.
Using a tandem mass tag (TMT)-based quantitative proteomics approach, we characterized the proteomes of individual patient-derived serum exosomes, identified exosomal protein signatures specific to TNBC patients, and filtered out differentially expressed proteins.
ORGANISM(S): Homo Sapiens 
PXD027696 |
GenomicsNCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
ProteomicsIdentified potential interacting proteins of WRN
We used anti-WRN antibody to perform immunoprecipitation assay through oncosphere lysates and identified a potential interacting protein candidate
ORGANISM(S): Homo Sapiens 
PXD044847 |
ProteomicsMolecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules
The production of secondary metabolites is one of the major mechanisms for beneficial rhizobacteria to antagonize plant pathogens. However, simultaneously producing large quantities of different secondary metabolites can pose great metabolic burdens and exerts a significant fitness cost on the produ...
ORGANISM(S): Pseudomonas Fluorescens F113 
2021-04-15 | PXD025403 |
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