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TranscriptomicsThe Relationship between Virus Replication and Host Gene Expression in Lymphatic Tissue during HIV-1 Infection
During HIV-1 infection, there is a massive perturbation of host gene expression, but as yet, genome-wide studies have not identified host genes affecting HIV-1 replication in lymphatic tissue, the primary site of virus-host interactions. In this study, we isolated RNA from the inguinal lymph nodes ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-21589 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphatic tissue from HIV-1 infected individuals reveals stage-specific, gene-expression signatures in HIV-1 infection
Untreated HIV-1 infection progresses through acute and asymptomatic stages to AIDS. While each of the three stages has well-known clinical, virologic and immunological characteristics, much less is known of the molecular mechanisms underlying each stage. Here we report lymphatic tissue microarray an...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-16363 | biostudies-arrayexpress
TranscriptomicsMultiple changes at the mucosal surface are induced by protective SIV vaccination
Systemic vaccination with the attenuated virus SIVmac239-∆Nef provides sterilizing or partial protection to rhesus monkeys challenged with WT SIV strains, providing important opportunities to study key immunological components of a protective host response. Here we show that intravenous vaccination...
ORGANISM(S): Macaca mulatta 
2012-05-30 | E-GEOD-33251 | biostudies-arrayexpress
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