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ProteomicsFascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments/The mitochondrial deoxyguanosine kinase is required for the self-renewal of cancer stem-like cell in lung adenocarcinoma
Project 1: The deregulation of the actin cytoskeleton has been extensively studied in metastatic dissemination. However, the post-dissemination role of the actin cytoskeleton dysregulation is poorly understood. Here we report that fascin, an actin-bundling protein, promotes lung cancer metastatic co...
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD014753 | Pride
Mitochondria Actin cytoskeleton Deoxyguanosine kinase Metastasis Fascin Lung cancer Stem-like cells 
UnknownDisulfiram in glioma: Literature review of drug repurposing.
Not available
S-EPMC9448899 | biostudies-literature
MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
ProteomicsThe H3K9me2-FOXG1-microRNA axis reduces cochlear hair cells damage by modulating autophagy in age-related hearing loss
Presbycusis, or age-related hearing loss (ARHL) [1], represents a major healthcare and social challenge in rapidly aging populations. ARHL significantly impairs communication, quality of life, and psychological well-being among older adults [2]. It typically manifests as a progressive, irreversible,...
ORGANISM(S): Mus Musculus 
2025-12-24 | PXD072393 |
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