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TranscriptomicsALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to abnormally enhance their interaction with SMN and reduce interaction with U1-snRN...
ORGANISM(S): Homo sapiens 
2015-02-10 | E-GEOD-64078 | biostudies-arrayexpress
ProteomicsThe insufficient activation of RIG-I-like signaling pathway in IBRS-2 cells contributes to highly efficient replication of porcine picornaviruses
Seneca Valley Virus (SVV) or commonly known as Senecavirus A (SVA), is one of picornavirus that is associated with vesicular disease and neonatal mortality in swine herds. However, the pathogenesis of SVV remains largely elusive. Our previous study found that SVV replicates extremely faster in porci...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-10-05 | PXD024003 | Pride
Senecavirus a  foot-and-mouth disease virus  rig-i like receptor signaling pathway  interferon  antiviral response 
ProteomicsThe insufficient activation of RIG-I-like signaling pathway in IBRS-2 cells contributes to highly efficient replication of porcine picornaviruses
Seneca Valley Virus (SVV) or commonly known as Senecavirus A (SVA), is one of picornavirus that is associated with vesicular disease and neonatal mortality in swine herds. However, the pathogenesis of SVV remains largely elusive. Our previous study found that SVV replicates extremely faster in porci...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-10-05 | PXD024002 | Pride
Senecavirus a  foot-and-mouth disease virus  rig-i like receptor signaling pathway  interferon  antiviral response 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063537 | Pride
Palmitoylation Senescence 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063840 | Pride
Osteoarthritis Senescence 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [III]
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063864 | Pride
Osteoarthritis Senescence 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [II]
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063859 | Pride
Osteoarthritis Il-1β 
ProteomicsQuantitative Proteomics Analysis with TMT Markers
Using TMT-labeled quantitative protein technique, we quantitatively analyzed the proteomes of three different resistant Bambusa pervariabilis × Dendrocalamopisis grandis under four different treatments: pathogenic fungi, pathogenic toxin, pathogenic fungi plus toxin and sterile water, and screened o...
ORGANISM(S): Bambusa Pervariabilis Bambusa Grandis 
PXD014363 |
ProteomicsNeofusiccocum parvum mycelium LC-MS/MS
TMT quantitative proteome of BH01 and BH03 of two Neofusiccocum parvum strains under different culture conditions
ORGANISM(S): Neofusicoccum Parvum 
2022-06-03 | PXD034277 |
ProteomicsProteomic and Acetylome Alterations in Obesity-related Osteoarthritic Mouse Cartilage
Male mice aged 4 weeks were housed under controlled conditions and assigned to either a normal diet or a high-fat diet for 16 weeks to establish an obesity model. At 12 weeks, osteoarthritis was induced using the destabilization of the medial meniscus procedure under anesthesia, while sham-operated ...
ORGANISM(S): Mus Musculus 
PXD062707 |
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