Proteomic and Acetylome Alterations in Obesity-related Osteoarthritic Mouse Cartilage

ABSTRACT: Male mice aged 4 weeks were housed under controlled conditions and assigned to either a normal diet or a high-fat diet for 16 weeks to establish an obesity model. At 12 weeks, osteoarthritis was induced using the destabilization of the medial meniscus procedure under anesthesia, while sham-operated mice served as controls. Eight weeks post-surgery, tibial cartilage tissues were collected, ensuring surrounding tissues were removed under a microscope. Tissues from 3-5 mice per group were pooled, and flash-frozen for subsequent lipidomic, proteomic, and acetylome analyses.

ORGANISM(S): Mus Musculus

SUBMITTER: Shunwu Fan  

PROVIDER: PXD062707 | iProX | Tue Apr 08 00:00:00 BST 2025

REPOSITORIES: iProX