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Protein samples were analyzed by Multidimensional Protein Identification Technology (MudPIT), as described previously. Briefly, precipitated proteins were resuspended in 30uL of 100mM Tris pH 8.5 with 8M urea to denature proteins. Cysteines were reduced and alkylated prior to digestion with recombi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-11 | MSV000087403 | MassIVE

Gastric cancer (GC) is a severe malignancy characterized by late diagnosis, poor prognosis and low survival rates. Its progression is often linked to chronic non-atrophic gastritis (CNAG) and chronic atrophic gastritis (CAG), which show atypical symptoms. Identifying biomarkers for CNAG, CAG and ...

2026-09-29 | MTBLS12186 | MetaboLights
We conducted a DIA-based proteomics study for 5 patients with CHD-PBS Syndrome, 5 patients with CHD-NPBS Syndrome, and 5 healthy adults to explore the biomarkers of PBS Syndrome.
ORGANISM(S): Homo Sapiens 
2022-08-30 | PXD036389 |
Our study is highly relevant to the fields of Medical Bioinformatics and Personalised Medicine, as it employs high-throughput omics technologies and bioinformatics analyses to uncover personalized biomarkers predictive of treatment response, thereby paving the way for tailored therapeutic strategi...
ORGANISM(S): Homo Sapiens 
2026-02-02 | PXD073923 |
Primary osteoporosis, manifesting as decreased bone mass and increased bone fragility, is a “silent disease” that is often ignored until a bone breaks. Accordingly, it is urgent to develop reliable biomarkers and novel therapeutic strategies for osteoporosis treatment. Here, we identified REGγ as...
ORGANISM(S): Homo Sapiens 
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059364 |
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