Sort   by:  
 Page size 
TranscriptomicsGene expression profiles of MBP-specific T cells during experimental autoimmune encephalomyelitis
2nd generation sequencing was used to compare expression profiles of MBP-specific T cells retrieved from blood, CSF, spinal cord meninges and parenchyma. The overall expression profiles were found to be very similar.However, genes regulated during T cell activation were found to be upregulated in T ...
ORGANISM(S): Rattus norvegicus 
2016-02-12 | E-GEOD-75488 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skin biopsies in cutaneous T-cell lymphoma
Cutaneous T cell lymphoma (CTCL) is defined by infiltration of activated and malignant T cells in skin. The clinical manifestations and prognosis in CTCL are highly variable. In this study, we hypothesized that gene expression analysis in lesional skin biopsies can improve understanding of the disea...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9479 | biostudies-arrayexpress
ProteomicsIntegrative proteomics and phosphoproteomics profiling and systems biology analysis reveal dynamic signaling networks and mTORC1-dependent mitochondrial function in T cell activation
The underlying mechanisms by which naïve T cells exit from quiescence after antigen stimulation remain elusive. Using multiplex isobaric labeling proteomics technology, we report unbiased, temporal profiling of whole proteome and phosphoproteome during the activation in the wild type and Rptor-/- T ...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-29 | PXD005492 | Pride
System biology T cell activation Mtorc1 Mass spectrometry Rptor Proteomic Phosphoproteomics Mitochondrial function 
GenomicsRegulating Interleukin-2 activity with engineered receptor signaling clamps
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. Previously, we engineered an IL-2 “superkine” (H9) with enhanced affinity for IL-2Rβ. Here, we describe next-generation IL-2 variants that...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-64713 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human non anaplastic T-cell lymphoma biopsies and cell lines
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 7 NKTCL biopsies, 2 NKTCL cell lines (SNK6, SNT8), 16 PTCL NOS biopsies, 2 NK cells samples | Biopsies and cell lines of NK/T-cell lymphoma, na...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-TABM-702 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human nasal NK/T-cell Lymphoma (8 tumor samples, 2 cell lines)
A ﾑCartes dﾒIdentite des Tumeursﾒ (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net ) | Human genome-wide CIT-aCGH-V6-4.4K : 8 NKTCL biopsies, 2 NKTCL cell lines. Biopsies and cell lines of NK/T-cell lymphoma, nasal-type (NKTCL) were subject to combine...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-TABM-791 | biostudies-arrayexpress
UnknownCombining CEUS and CT/MRI LI-RADS major imaging features: diagnostic accuracy for classification of indeterminate liver observations in patients at risk for HCC.
Not available
S-EPMC11991985 | biostudies-literature
MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
TranscriptomicsDiagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)
Cutaneous T-cell lymphomas (CTCL) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult due to a clinical and histological resemblance to benign inflammatory skin diseases. To address if microRNA (miRNA) profiling can discriminate CTCL from benig...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31408 | biostudies-arrayexpress
UnknownMS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle.
Not available
S-EPMC2967469 | biostudies-literature
Sort   by:  
 Page size