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GenomicsChIP-seq of Tcfap2c in Neu mammary cancer cells
Tumors were harvested from mice carrying the rat activated Neu-oncogene and made into a single cell suspension. ChIP-SEQ was carried out as previously described in Kulak MV, Cyr AR, Woodfield GW, Bogachek M, Spanheimer PM, Li T et al. Transcriptional regulation of the GPX1 gene by TFAP2C and aberran...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-61394 | biostudies-arrayexpress
GenomicsWhole Cell Extract
Most human genes are loaded with promoter proximally paused RNA polymerase II (RNAP II) molecules that are poised for release into productive elongation by P-TEFb. Gdown1, a protein that renders RNAP II responsive to mediator, is involved in RNAP II elongation control. During in vitro transcription ...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-35882 | biostudies-arrayexpress
GenomicsFunctional association of Gdown1 with RNA Polymerase II in Human
Most human genes are loaded with promoter proximally paused RNA polymerase II (RNAP II) molecules that are poised for release into productive elongation by P-TEFb. Gdown1, a protein that renders RNAP II responsive to mediator, is involved in RNAP II elongation control. During in vitro transcription ...
ORGANISM(S): Homo sapiens 
2012-01-13 | E-GEOD-32442 | biostudies-arrayexpress
GenomicsRenormalization of GSE32442 and GSE33128
Raw data from GSE32442 and GSE33128 and the input dataset for GSE32442 were renormalized by using reads per million. 11 samples from GSE32442 and GSE33128
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-35878 | biostudies-arrayexpress
GenomicsRenormalization of GSE32442 and GSE33128 plus 1 control sample
This SuperSeries is composed of the following subset Series: GSE35878: Renormalization of GSE32442 and GSE33128 GSE35882: Whole Cell Extract Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-35886 | biostudies-arrayexpress
TranscriptomicsRe-analysis of E-MTAB-1585
Raw data from E-MTAB-1585 was normalized by using reads per million. https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1585/ Strand specific RNA-Seq data E-MTAB-1585 was normalized and subtracted control from knockdown to generate tracks that more clearly displayed the unusual pattern of RNA exp...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-50860 | biostudies-arrayexpress
GenomicsTranscriptional Regulation of the GPX1 Gene by TFAP2C and Aberrant CpG Methylation in Human Breast Cancer
The complexity of gene regulation has created obstacles to defining mechanisms that establish the patterns of gene expression characteristic of the different clinical phenotypes of breast cancer. Transcription factor TFAP2C plays a critical role in the regulation of both estrogen receptor-alpha (ERM...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-36351 | biostudies-arrayexpress
GenomicsSumoylation Pathway Is Required to Maintain the Basal Breast Cancer Subtype
This study is an attempt to characterize the molecular basis for the functional differences between TFAP2A and TFAP2C. Recent findings have highlighted a critical role for the TFAP2C (AP-2M-NM-3) transcription factor in maintaining the luminal phenotype through the regulation of luminal-associated g...
ORGANISM(S): Homo sapiens 
2014-04-12 | E-GEOD-44257 | biostudies-arrayexpress
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