Sumoylation Pathway Is Required to Maintain the Basal Breast Cancer Subtype

ABSTRACT: This study is an attempt to characterize the molecular basis for the functional differences between TFAP2A and TFAP2C. Recent findings have highlighted a critical role for the TFAP2C (AP-2M-NM-3) transcription factor in maintaining the luminal phenotype through the regulation of luminal-associated genes. Of particular interest is that the highly homologous AP-2 family member, TFAP2A (AP-2M-NM-1), is expressed in luminal breast cancer but appears to have a functionally distinct role in gene regulation. There is 83% similarity between TFAP2A and TFAP2C with 76% identity in the carboxyl-half of the proteins containing the DNA binding and dimerization domains. Although the two family members appear to have complementary and overlapping roles in regulating neural crest development, they have

ORGANISM(S): Homo sapiens

SUBMITTER: Tiandao Li 

PROVIDER: E-GEOD-44257 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress