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ProteomicsPDCD6 modulates LC3-associated phagocytosis-mediated antimicrobial defense by regulating lactate metabolism
LC3-associated phagocytosis (LAP) is critical in host defense against invading pathogens, but the molecular mechanism for LAP activation is still unclear. Here, we find programmed cell death 6 (PDCD6) as a negative regulator of LAP. PDCD6 deficiency in mice and macrophages induces enhanced bacterici...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD056047 | Pride
Lactate Lap Pdcd6 
TranscriptomicsSingle-cell and single-nucleus RNAseq of the human and mouse skeletal muscle across age
This study aims to characterize the diversity of cell types in human skeletal muscle across age using two complementary technologies: single-cell and single-nucleus sequencing, which provide a comprehensive coverage of cell types in the muscle. We leveraged the aforementioned datasets to study chang...
ORGANISM(S): Mus musculus 
2024-03-07 | E-MTAB-13874 | biostudies-arrayexpress
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