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TranscriptomicsRapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
Here, we report synergistic inhibition of glycogen synthase kinase 3 (GSK3), transforming growth factor β (TGF β), and Notch signaling pathways by small molecules can efficiently convert monolayer cultured hESCs into homogenous primitive neuroepithelium within one week under chemically defined condi...
ORGANISM(S): Homo sapiens 
2011-04-28 | E-GEOD-28595 | biostudies-arrayexpress
ProteomicsN-glycoproteomic profiling reveals new therapeutic targets against coronavirus infestation which may be involved in Cepharanthine’s intervention
N-glycosylation is an important post-translational modification involved in protein folding, signal transduction, extracellular matrix (ECM) organization and immune response. Recent evidence shows that SARS-CoV-2 Spike protein is highly glycosylated and it may be potential target in viral pathology ...
ORGANISM(S): Chlorocebus sabaeus 
2022-08-12 | PXD021297 | Pride
N-glycoproteomic；cepharanthine；sars-cov-2；gx_p2v  cellular model  therapeutic target 
MetabolomicsTranscriptomic and metabolomic analysis of liver cirrhosis
Liver cirrhosis is one of the leading causes of decreased life expectancy worldwide. However, the molecular mechanisms underlying the development of liver cirrhosis remain unclear. In this study, we performed a comprehensive analysis using transcriptome and metabolome sequencing to explore the genes...
2024-08-07 | MTBLS5665 | MetaboLights
UnknownIntravenous tirofiban following successful reperfusion in intracranial large artery atherosclerotic stroke: A secondary analysis of a randomized clinical trial.
Not available
S-EPMC10646994 | biostudies-literature
ProteomicsThe role of neutrophils on SF protein carbamylation
The role of neutrophils on SF protein carbamylation
ORGANISM(S): Homo Sapiens 
2024-12-20 | PXD059136 |
TranscriptomicsConversion of Epiblast Stem Cells to Embryonic Stem Cells by Small Molecules
Recently, (in vitro) pluripotent EpiSCs were derived from the post-implantation egg cylinder stage epiblasts of mouse and rat. These EpiSCs resemble and correspond very closely to the conventional human embryonic stem cells (hESCs) in the colony morphology and culture/signaling requirements for main...
ORGANISM(S): Mus musculus 
2010-10-30 | E-GEOD-17664 | biostudies-arrayexpress
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