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Proteomicsproteomic data of exosomes derived from NIT-1 cells treated with and without high glouse
NIT-1 cells treated with high glucose were detected by RNAseq to explore the molecular mechanism of high glucose accelerating the onset of type 1 diabetes and the proteome of NIT-1-cells-derived exosomes were also discussed.
ORGANISM(S): Mus musculus (Mouse) 
2022-12-02 | PXD032768 | Pride
Nit-1 cell exosomes type 1 diabetes 
TranscriptomicsA shared transcriptional program in early breast neoplasias despite genetic and clinical distinctions
The earliest recognizable stages of breast neoplasia are lesions that represent a heterogeneous collection of epithelial proliferations currently classified based on morphology. Their role in the development of breast cancer is not well understood but insight into the critical events at this early s...
ORGANISM(S): Homo sapiens 
2014-05-04 | E-GEOD-47462 | biostudies-arrayexpress
TranscriptomicsSmall RNA expression and caste differentiation in the honeybee
Honeybees are very important eusocial insects and are involved in the pollination of many plants. Queen bees and worker bees develop from the same fertilized eggs, and are thus genetically identical despite their substantial behavioural and physiological differences. The mechanism governing developm...
ORGANISM(S): Apis mellifera 
2014-07-28 | E-GEOD-52630 | biostudies-arrayexpress
TranscriptomicsFeeding with miR-184 affects the mRNA expression profile of queen larvae
By comparing mRNA profiles of the two groups of bee larvae (treated by miR-184 and water), we found that there were 279 mRNAs which were differently expressed between treated and control larvae (ratio>2 and p<0.01), of which 200 mRNAs were down-regulated in treated larvae, and 79 mRNAs were down-reg...
ORGANISM(S): Apis mellifera 
2014-01-06 | E-GEOD-44911 | biostudies-arrayexpress
TranscriptomicsRecipe for a busy bee: MicroRNAs in honey bee caste determination
Social caste determination in the honey bee is assumed to be determined by the dietary status of the young larvae and translated into physiological and epigenetic changes through nutrient-sensing pathways. We have employed Illumina/Solexa sequencing to examine the small RNA content in the bee larval...
ORGANISM(S): Apis mellifera 
2014-01-06 | E-GEOD-44853 | biostudies-arrayexpress
ProteomicsNovel Peptidomic Analysis Identifies Peptide Clusters with Potential for Disease Diagnosis and Dysregulated Proteolytic Processing
Mass spectrometry-based peptidomics provides a comprehensive approach to delineate the global proteolytic landscape of diseases and to identify potential biomarkers. However, current data analysis methods struggle to distill the peptidomic signatures of diseases. In this study, we conducted a peptid...
ORGANISM(S): Homo Sapiens 
2025-04-02 | PXD062496 |
ProteomicsProteomic and Acetylome Alterations in Obesity-related Osteoarthritic Mouse Cartilage
Male mice aged 4 weeks were housed under controlled conditions and assigned to either a normal diet or a high-fat diet for 16 weeks to establish an obesity model. At 12 weeks, osteoarthritis was induced using the destabilization of the medial meniscus procedure under anesthesia, while sham-operated ...
ORGANISM(S): Mus Musculus 
2025-04-08 | PXD062707 |
TranscriptomicsTranscriptional profiling of lncRNAs and novel transcribed regions across a diverse panel of archived human cancers
Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis. Long non-coding RNAs (lncRNAs), as a new, relatively unstudied class of transcripts, provide a rich opportunity to identify both functional d...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-GEOD-28866 | biostudies-arrayexpress
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