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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
UnknownR229I substitution from oseltamivir induction in HA1 region significantly increased the fitness of a H7N9 virus bearing NA 292K.
The proportion of human isolates with reduced neuraminidase inhibitors (NAIs) susceptibility in highly pathogenic avian influenza (HPAI) H7N9 virus was high. These drug-resistant strains showed good replication capacity without serious loss of fitness. In the presence of oseltamivir, R229I substitut...
S-EPMC467099 | biostudies-literature
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
ProteomicsData-Independent Acquisition Proteomics Reveals Circulating Biomarkers of Coronary Chronic Total Occlusion in Humans
The pathophysiology of chronic coronary total occlusion (CTO) has not been fully elucidated. In the present study, we aimed to investigate the potential plasma biomarkers associated with the pathophysiologic progression of CTO and identify protein dynamics in the plasma of CTO vessels immediately af...
ORGANISM(S): Homo Sapiens 
PXD034267 |
ProteomicsIntegrated Proteogenomic Characterization of Localized Prostate Cancer Identifies Biological Insights and Subtype-Specific Therapeutic Strategies
We profiled the genome, transcriptome, proteome and phosphoproteome of 145 cases of localized prostate cancer (PCa) in Chinese patients and revealed three subtypes with distinct molecular features. We integrated multi-omic data to refine molecular subtyping of localized PCa, and identified NANS as a...
ORGANISM(S): Homo Sapiens 
PXD056748 |
ProteomicsProteomics of prostate cancer orthotopic transplanted mice
We profiled the proteomics of prostate cancer orthotopic transplanted mice.
ORGANISM(S): Mus Musculus 
2025-01-21 | PXD058636 |
ProteomicsProteomics of prostate cancer cell lines
We profiled the proteomics of prostate cancer (PCa) cell lines.
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-12-06 | PXD058635 |
ProteomicsData Submission: Proteomic Identification of Proteins Interacting with CircRNA
This project submits the proteomic dataset of proteins interacting with the specific circular RNA Circ-018468, identified by ChIRP-MS (Chromatin Isolation by RNA Purification coupled with Mass Spectrometry). The experiment was performed using cell samples, with a negative control (non-specific probe...
ORGANISM(S): Mus Musculus 
2025-12-23 | PXD072338 |
UnknownUltrahigh-energy gamma-ray emission associated with black hole-jet systems.
Black holes (BHs), one of the most intriguing objects in the universe, can manifest themselves through electromagnetic radiation initiated by the accretion flow. Some stellar-mass BHs drive relativistic jets when accreting matter from their companion stars, forming microquasars. Non-thermal emission...
S-EPMC12746838 | biostudies-literature
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