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MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
ProteomicsMetabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in 2 nonalcoholic steatohepatitis
In this study Guo et al. revealed an endocrine pathway regulated by skeletal muscle IRF4 that manipulates liver pathology. Mice with skeletal muscle specific ablation of IRF4 show ameliorated liver steatosis, inflammation, and fibrosis, without changes in body weight on nonalcoholic steatohepatitis ...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-13 | PXD045324 | Pride
Mouse serum lcms 
ProteomicsLPS-induced TIR domain complex acetylation activated TLR4/MAL/MyD88 signal pathway in sepsis
Among the diseases caused by Toll-like receptor 4 (TLR4) abnormal activation by bacterial endotoxin, sepsis is the most dangerous one. The reprogramming of macrophages plays a crucial role in orchestrating the pathogenesis of sepsis. However, the precise mechanism underlying TLR4 activation in macro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-01 | PXD052433 | Pride
Tlr4 Myd88 Sepsis 
ProteomicsUSP8 maintains ESC stemness via deubiquitination of EPG5
The coiled-coil domain of EPG5 was synthesized as follows: Biotin-MNKNEAVSQQIHVLQKEVRQLQAE AAQ (from Beijing SciLight Biotechnology, LCC). 1 mg of this short peptide was incubated with ES cells lysates followed by immunoprecipitation with anti-biotin beads. The precipitates were extensively washed w...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-25 | PXD012563 | Pride
I.e.mouse.escs.epg5.usp8.lc-msms 
Proteomicsglutathione peroxidase 1 (GPX1) interactome
Native protein extracts from 2-week-old seedlings of wild-type and GPX1-OE lines were used to identify interactions partners of glutathione peroxidase 1 in rice.
ORGANISM(S): Oryza Sativa 
2022-07-07 | PXD027157 | JPOST Repository
Proteomicspp6 is recruited in TNFalpha induced complex I
We identify pp6 is recruited in complex I induced by TNFalpha.
ORGANISM(S): Mus Musculus 
2021-12-14 | PXD030377 |
ProteomicsProteomics and Organoid Culture Reveal the Underlying Pathogenesis of Hashimoto's Thyroiditis
To understand Hashimoto's Thyroiditis and translate this knowledge to clinical applications, we took mass spectrometric analysis on thyroid tissue fine-needle puncture from HT patients and healthy people in an attempt to make a further understanding of the pathogenesis of Hashimoto's Thyroiditis.
ORGANISM(S): Homo Sapiens 
2021-09-10 | PXD028448 |
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