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UnknownComparative evaluation of large language models in delivering guideline-compliant recommendations for topical NSAID use in musculoskeletal pain: a multidimensional analysis.
Not available
S-EPMC12568900 | biostudies-literature
ProteomicsThe proteomics sequencing of two engineered yeast strains CEN-Cho and CEN-Cho-MVA
An MS-based proteomics approach was utilized to monitor the changes in protein abundance between the CEN-Cho and CEN-Cho-mMVA. A total of 702 differently expressed proteins (DEPs) were identified in the comparison group.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-08-24 | PXD074200 | Pride
Proteomics analysis 
MetabolomicsChaihu Shugan prevents cholesterol gallstone formation by ameliorating the microbiota dysbiosis and metabolic disturbance in mice

INTRODUCTION: Cholesterol gallstone (CGS) is a biliary tract disorder requiring treatment in approximately 20% of patients. The efficacy of Chaihu Shugan in preventing CGS recurrence after successful treatment remains uncertain.

METHODS: We examined the

2024-01-29 | MTBLS7181 | MetaboLights
UnknownMutation of a major CG methylase in rice causes genome-wide hypomethylation, dysregulated genome expression, and seedling lethality.
Not available
S-EPMC4115543 | biostudies-literature
TranscriptomicsA Novel Neuron-specific Histone H4K20 Demethylase LSD1n Promotes Transcriptional Elongation and is Essential for Learning and Memory
LSD1n regulates transcriptional elongation by removing H4K20 methylation. Identification of genome-wide binding sites of LSD1, and examination of the histone modifications upon LSD1n deletion in primary cortical neurons
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-63271 | biostudies-arrayexpress
TranscriptomicsOryza sativa Transcriptome or Gene expression
To investigate impacts of genome-wide loss of Cytosine methylation at CG sites (mCs) on global expression of protein-coding genes (henceforth referring to genes), we conducted deep RNA-seq analysis on OsMET1-2−/− relative to its sibling WT and heterozygote (OsMET1-2+/−), each with two biologic...
ORGANISM(S): Oryza sativa 
2014-08-09 | E-MTAB-4224 | biostudies-arrayexpress
TranscriptomicsLigand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stress f...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63202 | biostudies-arrayexpress
GenomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [ChIP-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64483 | biostudies-arrayexpress
TranscriptomicsEnhancer-bound LDB1 Regulates a Corticotrope Promoter Pausing Repression Program [GRO-seq]
Substantial evidence supports the hypothesis that enhancers are critical regulators of cell type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and re...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-64515 | biostudies-arrayexpress
ProteomicsProteomic analysis of giant panda testicular tissue
Proteomic analysis of giant panda testicular tissue of different age groups
ORGANISM(S): Ailuropoda Melanoleuca 
2024-03-27 | PXD051003 |
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