Sort   by:  
 Page size 
ProteomicsTrimodal probe for proteome profiling of AchE in animals
Acetylcholinesterase (AChE) is a cholinergic enzyme that hydrolyzes esters of the neurotransmitter acetylcholine (Ach). Aberrant activity of AChE is closely associated with various neurodegenerative diseases and cancer. Current chemical probes for AChE detection mostly rely on fluorescence readout a...
ORGANISM(S): Mus Musculus 
PXD063264 |
ProteomicsLysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals
We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenou...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD058513 |
ProteomicsSynergistic Therapeutic Effects of D-Mannitol-Cerium-Quercetin (Rutin) Coordination Polymer Nanoparticles on Acute Lung Injury
In our latest study, we pioneered the use of D-Mannitol-Cerium-Quercetin/Rutin coordination polymer nanoparticles (MCQ/R NPs) as a potential remedy for ALI. our in vivo studies with LPS-induced ALI mice showed significant mitigation of lung tissue inflammation. This groundbreaking research presents ...
ORGANISM(S): Mus Musculus 
PXD051350 |
ProteomicsMi-2β promotes immune evasion in melanoma by activating EZH2 methylation
For identification of Mi-2β-interacting proteins, B16F10 cells (1 × 108) were collected and washed three times with PBS and lysed in lysis buffer on ice for 30 min. Cell lysates were collected and then isolated over night by anti-Mi-2β magnetic agarose beads. The anti-Mi-2β magnetic agarose beads we...
ORGANISM(S): Mus Musculus 
2024-02-18 | PXD049467 |
ProteomicsMARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA
Proteomic dataset generated in the project for study the molecular function of MARTRE proteins
ORGANISM(S): Mus Musculus 
2024-11-25 | PXD051636 |
ProteomicsProteomic analyses of plasma-derived exosomes in IgG4-RD and its potential role in B cell differentiation and tissue damage
Objective: This study aimed to investigate plasma exosome profiling of IgG4-RD and its potential role in B cell differentiation and tissue damage. Methods: One hundred untreated IgG4-RD patients and 135 sex, age matched healthy controls (HCs) were enrolled in this study. A combination of liquid chro...
ORGANISM(S): Homo Sapiens 
PXD021441 |
Sort   by:  
 Page size