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MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Human UPLC-MS/MS assays)

Progressive decline in lung function is a hallmark of chronic obstructive pulmonary disease (COPD). Although airway dysbiosis occurs in COPD, whether it contributes to disease progression remains unknown. Here, through a longitudinal analysis on 181 COPD individuals from two large cohorts involvi...

2023-06-12 | MTBLS5423 | MetaboLights
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Murine UPLC-MS/MS assays)

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression remains unknown. Here we showed, through a longitudinal analysis on two cohorts involving four UK centers, that basel...

2023-06-12 | MTBLS6894 | MetaboLights
UnknownDiversity of Colletotrichum Species Causing Apple Bitter Rot and Glomerella Leaf Spot in China.
Not available
S-EPMC9322356 | biostudies-literature
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
TranscriptomicsExon Array Expression Profiling of HCT116 (p53null) cells transfected with wildtype p53 and 6 p53 mutants
The tumor suppressor protein p53 functions to regulate diverse cellular processes including apoptosis, cell cycle, senescence and metabolism. Act as a master transcription factor, it can transcriptionally regulate the gene expression of many downstream target genes. p53 is frequently mutated in canc...
ORGANISM(S): Homo sapiens 
2013-08-19 | E-GEOD-49046 | biostudies-arrayexpress
ProteomicsSerum Peptidome Profiles Immune Response of COVID-19 Vaccine Administration
The study shows the promise of MALDI-TOF MS-based serum peptidome analysis for the assessment of immune responses activated by COVID-19 vaccination, and discovered a panel of serum peptides biomarkers for COVID-19 vaccination and for NAbs generation. The method developed in this study can help not o...
ORGANISM(S): Homo Sapiens 
2022-08-19 | PXD036159 |
TranscriptomicsProinflammatory effect of Pseudomonas aeruginosa hook protein FlgE on human corneal epithelial cells
Recombinant protein of Pseudomonas aeruginosa hook protein FlgE was added to cultured human corneal epithelial cell line for 4 hours and the mRNA expression profiling was performed using Agilent 8*60K array and dual labeling. Three triplicates were included for FlgE treatment and PBS control respect...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-58422 | biostudies-arrayexpress
TranscriptomicsThe Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends
Chromosomal double-strand breaks (DSBs) are resected by 5M-bM-^@M-^Y-nucleases to form 3M-bM-^@M-^Y single-strand DNA (ssDNA) substrates for binding by homologous recombination and DNA damage checkpoint proteins. Two redundant pathways of extensive resection were described both in cells and in vitro...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-04 | E-GEOD-38601 | biostudies-arrayexpress
ProteomicsHDL Quality Features Revealed by Proteome-Lipidome Connectivity are Associated with Atherosclerotic Disease
The “quality” rather than “quantity” of lipoprotein particles is more relevant to cardiovascular diseases (CVD), since lipoprotein particles are highly heterogeneous. However, the targeted separation, detection, and exploration of the heterogeneous on omic-scale for lipoprotein remain challenging an...
ORGANISM(S): Homo Sapiens 
2020-02-15 | PXD017529 |
ProteomicsHDL quality feature revealed by proteome-lipidome connectivity are associated with atherosclerotic disease
Lipoprotein, especially high density lipoprotein (HDL) particles are composed of multiple heterogeneous subgroups containing various proteins and lipids. The molecular distribution among these subgroups is closely related to cardiovascular disease (CVD). Here, we established high-resolution proteomi...
ORGANISM(S): Oryctolagus Cuniculus Homo Sapiens 
2021-09-03 | PXD028209 |
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