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ProteomicsProteotranscriptomic Analyses in Laser-Induced Choroidal Neovascularization
To probe into the molecular mechanism underlying the onset of choroidal neovascularization (CNV), integrated transcriptomic and proteomic analyses of the retinas in mice with laser-induced CNV were performed by using RNA sequencing and tandem mass tag.
ORGANISM(S): Mus Musculus 
2023-02-09 | PXD039971 |
TranscriptomicsExpression profiling reveals novel pathways in the transformation of melanocytes to melanomas. II
Spotted oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma cells...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4576 | biostudies-arrayexpress
ProteomicsHypothalamic malate dehydrogenase 2 (MDH2) modulates systemic glucose metabolism through oxytocin-mediated thermogenesis
Bariatric surgery improves hyperglycemia in obesity and type 2 diabetes (T2D), yet its central mechanisms remain unclear. Through cerebrospinal fluid proteomic profiling of rats, we identify reduced central malate dehydrogenase 2 (MDH2) levels that correlate with surgery-induced restoration of normo...
ORGANISM(S): Rattus Norvegicus 
2025-12-19 | PXD072275 |
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