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TranscriptomicsSustained expression of cyclin D1 or cyclin D1/KE in mouse mammary gland
Analysis of mammary glands from tet-inducible(rtTA) transgenic mice expressing cyclin D1 using Affymetrix Mouse Gene 1.0 ST GeneChip arrays. MMTV-rtTA transgenic mice (MMTV-Mouse Mammary Tumor Virus promoter) were cross-mated to cyclin D1 transgenic mice under control of tet operon. 8-week-old tetr...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-43216 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of advanced murine K-RasG12V lung adenocarcinomas
We aimed to analyze the transcriptional profile of full-blown murine lung adenocarcinomas driven by K-RasG12V oncogene. We used a GEM model of lung adenocarcinoma driven by a resident K-RasG12V oncogene. On average, tumors were collected 10 months after Adeno-CRE infection.
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-65257 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of normal lung cells and K-RasG12V driven hyperplasias
We aimed to analyze the transcriptional profile of lung epithelial cells early after the expression of a resident K-RasG12V oncogene. This approach was based on the rationale that valuable therapeutic targets should be easier to detect in the first stages of tumor development due to tumor heterogene...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-65256 | biostudies-arrayexpress
UnknownSIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.
Not available
S-EPMC4687752 | biostudies-literature
UnknownComparative transcriptome analysis between inbred lines and hybrids provides molecular insights into K+ content heterosis of tobacco (Nicotiana tabacum L.).
Not available
S-EPMC9389268 | biostudies-literature
ProteomicsP.aeruginosa PAO1+Pht Tandem Mass Tag (TMT)-based quantitative proteomic analysis
To study the changes in the proteomics profile of P. aeruginosa PAO1 upon Pht addition, TMT was used as the labeling strategy for comparative quantitative proteomic analysis.
ORGANISM(S): Pseudomonas Aeruginosa 
2022-03-18 | PXD032384 |
TranscriptomicsGEMM CRC collection analysis
A collection of genetically engineered mouse models (GEMM) of colorectal cancer (CRC) were created, and primary tumors from these GEMMs were analyzed. Primary CRC tumors from these GEMMs were genotyped to confirm that they contain the core genetic lesions of interest, including APC, P53, KRAS, and B...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-50794 | biostudies-arrayexpress
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
TranscriptomicsResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
We explored potential bypass mechanisms to PI3K/mTOR-directed therapy in KRAS mutant CRC models, utilizing genetically engineered mouse models (GEMM) to generate acquired resistance to the targeted dual PI3K/mTOR small molecule inhibitor PF-04691502. Transcriptomic analysis revealed a dynamic stem-l...
ORGANISM(S): Mus musculus 
2014-08-31 | E-MTAB-2510 | biostudies-arrayexpress
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