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TranscriptomicsRenal medullary genes in salt-sensitive hypertension
Substitution of chromosome 13 from Brown Norway BN/SsNHsd/Mcw (BN/Mcw) rats into the Dahl salt-sensitive SS/JrHsd/Mcw (SS/Mcw) rats resulted in substantial reduction of blood pressure salt sensitivity in this consomic rat strain designated SSBN13. In the present study, we attempted to identify genes...
ORGANISM(S): Rattus norvegicus 
2010-06-30 | E-GEOD-3608 | biostudies-arrayexpress
TranscriptomicsmiR-29c Targets Tropomyosin-1M-NM-1 and Is Down-regulated in Rat Remnant Kidneys and IgA Nephropathy Patients with Interstitial Fibrosis
MicroRNAs (miRNAs) are small regulatory RNA molecules that modulate the activity of specific mRNA targets and play important roles in a wide range of physiologic and pathologic processes. We hypothesized that miRNAs might be involved in the progression of CKD. In our previous studies we found chro...
ORGANISM(S): Rattus norvegicus 
2013-01-08 | E-GEOD-28471 | biostudies-arrayexpress
ProteomicsProteomic Profiles of Human Arterioles Isolated from Fresh Adipose Tissue or Following Overnight Storage
Arterioles are key determinants of the total peripheral vascular resistance, which, in turn, is a key determinant of arterial blood pressure. However, the amount of protein available from one isolated human arteriole may be less than 5µg, making proteomic analysis challenging. In addition, obtaining...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD044454 | Pride
Arterioles Tmt labeled mass spectrometry Booster channel Overnight storage Proteomics 
TranscriptomicsInsights into Dahl salt-sensitive hypertension revealed
The results of this study identified a number of pathways potentially important for the amelioration of hypertension and renal injury in SS-13BN/Mcw rats, and these results generated a series of testable hypotheses related to the role of the renal medulla in the complex mechanism of salt-sensitive h...
ORGANISM(S): Rattus norvegicus 
2010-06-30 | E-GEOD-3588 | biostudies-arrayexpress
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