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TranscriptomicsSex-specific effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene x environment interactions
prenatal stress response, genetic modification Background: Prenatal stress (PS) exposure has been shown to increase the risk for emotional disorders in later life. Furthermore, the serotonin transporter (5-HTT) genotype is suggested to exert a modulating effect on the association between early life ...
ORGANISM(S): Mus musculus 
2011-12-12 | E-GEOD-26025 | biostudies-arrayexpress
TranscriptomicsProstate Cancer Gene Expression Changes with Neoadjuvant Hormone Therapy
Men with clinically localized prostate cancer were treated with 0 to 9 months of neoadjuvant hormone suppression prior to prostatectomy. Keywords: microarray, hormone, 9 men with prostate cancer were assigned to neoadjuvant hormone suppression therapy for 3-6, 6, or 0 months.
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9983 | biostudies-arrayexpress
TranscriptomicsProstate Cancer Gene Expression Changes after Treatment with Neoadjuvant Dutasteride
To identify molecular changes underlying the chemopreventive or tumor promoting effects of SRD5A inhibition, we profiled gene expression changes in benign prostate epithelium from patients with PCa treated with dutasteride, a dual SRD5A inhibitor. Subjects were aged 45-80 years with clinically local...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-GEOD-9972 | biostudies-arrayexpress
TranscriptomicsComparison of Normal Prostate Fibroblasts Overexpressing Cyclin D1 and Carcinoma Associated Fibroblasts
The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-6936 | biostudies-arrayexpress
TranscriptomicsIdentification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.
Microarray analysis has been useful for identifying the targets of many transcription factors. However, gene expression changes in response to transcription factor perturbation reveal both direct transcriptional targets and secondary gene regulation. By integrating RNA interference, gene expression ...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15440 | biostudies-arrayexpress
TranscriptomicsA Wnt-Bmp feedback circuit controls inter-tissue signaling dynamics in tooth organogenesis
Gene expression profiling of the epithelial and mesenchymal compartments of the developing mouse tooth using Laser Capture Microdissected (LCM) or enzymatic treatment with Dispase to isolate the dental epithelial and mesenchymal tissue, over a developmental period from E10.0-E14.5. The data is also ...
ORGANISM(S): Mus musculus 
2012-01-13 | E-GEOD-32321 | biostudies-arrayexpress
GenomicsGenome wide localization of chromatin bound NUP98-PHF23 (NP23)
We analyzed the genome wide localization of H3K4me3, H3K27me3 and the NUP98-PHF23 (with V5 tag) fusion protein which binds H3K4me3 via its PHD finger, using ChIP-seq. Results correlated with gene expression profiles. NUP98-PHF23 bound only 1.6% of H3K4me3 marks including Hoxa/b + Meis1. Assess H3K4m...
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-54786 | biostudies-arrayexpress
TranscriptomicsRNAi knockdown of SCAI in human mammary carcinoma cells
To investigate the role of SCAI (suppressor of cancer cell invasion) on gene expression, MDAMB-231 mammary carcinoma cells were transfected by SCAI siRNA and global mRNA expression profiling was performed in comparison to mock siRNA transfecte cells. Experiments were performed in three independent b...
ORGANISM(S): Homo sapiens 
2009-02-15 | E-MEXP-1985 | biostudies-arrayexpress
TranscriptomicsNotch signaling/MyoD double deficient embryonic muscle progenitors
Skeletal muscle growth and regeneration rely on myogenic progenitor and satellite cells, the stem cells of postnatal muscle. Elimination of Notch signals during mouse development results in premature differentiation of myogenic progenitors and formation of very small muscle groups. Here we show that...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-39379 | biostudies-arrayexpress
GenomicsRPD3-Q3451.14-16 hr OR embryo.Solexa
modENCODE_submission_5125 This submission comes from a modENCODE project of Gary Karpen. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We aim to determine the locations of 125 chromosomal proteins across the Drosophila melanogaster genome. The proteins under s...
ORGANISM(S): Drosophila melanogaster 
2013-05-28 | E-GEOD-47305 | biostudies-arrayexpress
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