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MetabolomicsThe telomere-to-telomere (T2T) genome of Peucedanum praeruptorum Dunn provides insights into the genome evolution and coumarin biosynthesis

BACKGROUND: Traditional Chinese medicine has used Peucedanum praeruptorum Dunn (Apiaceae) for a long time. Various coumarins, including the significant root constituents Praeruptorin (A-E), are the active constituents of the dried roots of P. praeruptorum. Previous trans...

2024-04-02 | MTBLS8679 | MetaboLights
ProteomicsProteomic profiling of anastomotic veins identifies neointimal hyperplasia biomarkers in autogenous arteriovenous fistula
Autogenous arteriovenous fistula is the preferred vascular access for end-stage renal disease (ESRD) patients receiving hemodialysis treatment; however, its failure, primarily due to neointimal hyperplasia (NIH), significantly impacts the quality of hemodialysis. This study employs proteomics techni...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD062024 | Pride
End-stage renal disease  hemodialysis  autogenous arteriovenous fistula  neointimal hyperplasia  proteomics 
TranscriptomicsGlobal gene expression profiles of Oryza sativa wild type Nipponbare and mutant coi1-13
To reveal the underlying molecular mechanism of jasmonate inhibits gibberellins signaling in rice, we performed transcriptional profiling of wild type nipponbare and mutant coi1-13 plants on a global scale using the Affymetrix GeneChip Rice Genome Array Rice young uppermost internodes were harvested...
ORGANISM(S): Oryza sativa 
2011-12-01 | E-GEOD-29577 | biostudies-arrayexpress
TranscriptomicsMicroarray Analysis of Gene Expression in Human Normal and Breast Cancer Cells
Differential gene expression between normal breast epithelial cells and the malignant counterpart was studied using microarray technique. We utilized GeneAlbum GEM 1-6 from Incyte Pharmaceuticals, Inc., which contains which contains 65,873 cDNA clones (57,172 clones excluding controls), representing...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2155 | biostudies-arrayexpress
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
ProteomicsA Cell-Permeable Photosensitizer for Selective Proximity Labeling and Crosslinking of Aggregated Proteome
Intracellular proteome aggregation is a ubiquitous disease hallmark with its composition associated with pathogenicity. Herein, we report on a cell-permeable photosensitizer (P8, Rose Bengal derivative) for selective photo-induced proximity labeling, crosslinking and identification of cellular aggre...
ORGANISM(S): Homo Sapiens 
2023-08-30 | PXD044948 |
ProteomicsIn-vivo crosslinking based affinity purification-mass spectrometry for targeting intracellular protein-protein interactions
Comprehensive interactome analysis of targeted proteins is of great significance to understand how pro-teins work together for functional regulation. Until now, affinity purification strategy with mass spec-trometry (AP-MS) has been recognized as the most widely used technique for studying protein-p...
ORGANISM(S): Homo Sapiens 
2022-12-01 | PXD038473 |
ProteomicsA Glycosidic-Bond-Based Mass-Spectrometry-Cleavable Cross-linker Enables In Vivo Cross-linking for Protein Complex Analysis
Chemical cross-linking mass spectrometry (CXMS) has emerged as a powerful technology to analyze protein complex structure and interaction. However, the spectral fragmentation behavior and spectral data retrieval of cross-linked peptides are more complex than single peptides. In this study, we design...
ORGANISM(S): Homo Sapiens Saccharomyces Cerevisiae 
2023-12-06 | PXD047554 |
ProteomicsOrthogonal Ionic Liquid-based Extraction Strategy Enables Amyloid-Specific Profiling of the Aggregate Proteome
Amyloid deposits are key pathological features of neurodegenerative diseases, yet their structural heterogeneity coupled with a stable β-sheet fibrillar architecture makes them extremely insoluble and difficult to isolate. Through systematic screening and molecular dynamics simulations, we identifie...
ORGANISM(S): Mus Musculus 
2025-10-17 | PXD069689 |
ProteomicsTargeting RANKL-Independent Osteoclastogenesis Overcomes Denosumab Resistance in ER+ Breast Cancer Bone Metastasis
Bone metastasis remains a major cause of morbidity in ER+ breast cancer, with RANKL inhibitor resistance emerging as a critical clinical challenge. Nearly 40% of patients develop progressive skeletal lesions despite denosumab therapy, highlighting an urgent need to identify resistance mechanisms and...
ORGANISM(S): Homo Sapiens 
2026-01-29 | PXD073739 |
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