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TranscriptomicsRegions of XY homology in the pig X chromosome and the boundary of the pseudoautosomal region
Background Sex chromosomes are subject to evolutionary pressures distinct from the remainder of the genome, shaping their structure and sequence content. We are interested in the sex chromosomes of domestic pigs (Sus scrofa), how their structure and gene content compares and contrasts with other mam...
ORGANISM(S): Sus scrofa 
2012-08-30 | E-GEOD-40244 | biostudies-arrayexpress
TranscriptomicsIncomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse
Mammals have evolved a mechanism to compensate for the difference in the number of X chromosome genes between XX females and XY males by inactivating one of the two X chromosomes in females. This X chromosome inactivation phenomenon is triggered by Xist gene, which is essential for X-inactivation to...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-27373 | biostudies-arrayexpress
TranscriptomicsRearrangement of CRLF2 in B-progenitor and Down syndrome associated acute lymphoblastic leukemia
Chromosomal aneuploidy and translocations are hallmarks of acute lymphoblastic leukemia (ALL), but many patients lack a recurring chromosomal alteration. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that results in the ex...
ORGANISM(S): Homo sapiens 
2009-10-18 | E-GEOD-16724 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-Sequencing of splenocytes from Four Core Genotype (FCG) mice
This repository contains single-cell gene expression profiling from mouse splenocytes of the Four Core Genotypes cross. By crossing mice with both a deletion of the sex-determining factor Sry on the Y-chromosome and a transgenic insertion of Sry on Chromosome 3 , four combinations of gonadal (testis...
ORGANISM(S): Mus musculus 
2024-10-14 | E-MTAB-13586 | biostudies-arrayexpress
UnknownCRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo.
Not available
S-EPMC4658030 | biostudies-literature
TranscriptomicsAltered DNA Methylation in Leukocytes with Trisomy 21
The primary abnormality in Down syndrome (DS), trisomy 21, is well known, but how this chromosomal gain produces the complex DS phenotype, including immune system defects, is not well understood. We profiled DNA methylation in total peripheral blood leukocytes (PBL) and T-lymphocytes from adults wit...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-25395 | biostudies-arrayexpress
GenomicsArchitecture of Epigenetic Reprogramming Following Twist1 Mediated Epithelial-Mesenchymal Transition [ChIP-seq]
Purpose: to characterize epigenetic changes following Twist1 mediated Epithelial-Mesenchymal Transition in human Methods: we characterized the epigenetic and transcriptome landscapes using whole genome transcriptome analysis by RNA-seq, DNA methylation by digital restriction enzyme analysis of meth...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-53023 | biostudies-arrayexpress
GenomicsArchitecture of Epigenetic Reprogramming Following Twist1 Mediated Epithelial-Mesenchymal Transition
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-53026 | biostudies-arrayexpress
GenomicsArchitecture of Epigenetic Reprogramming Following Twist1 Mediated Epithelial-Mesenchymal Transition [DREAM-seq]
Purpose: to characterize epigenetic changes following Twist1 mediated Epithelial-Mesenchymal Transition in human Methods: we characterized the epigenetic and transcriptome landscapes using whole genome transcriptome analysis by RNA-seq, DNA methylation by digital restriction enzyme analysis of meth...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-53025 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus RNA-Sequencing (sci-RNA-seq3) of whole livers from 48 Four Core Genotype (FCG) mice
This repository contains single-nucleus gene expression profiling from 48 mouse livers of the Four Core Genotypes cross. By crossing mice with both a deletion of the sex-determining factor Sry on the Y-chromosome and a transgenic insertion of Sry on Chromosome 3, four combinations of gonadal (testis...
ORGANISM(S): Mus musculus 
2024-12-24 | E-MTAB-13987 | biostudies-arrayexpress
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