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ProteomicsInduced Degradation of Lineage-specific Oncoproteins Underlies the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer (batch2-6)
A subset of small cell lung cancer (SCLC) shows a clinical response to PARP inhibitors (PARPi) despite being proficient in homologous repair pathways. However, the underlying mechanism(s) of PARPi sensitivity is poorly understood. We performed quantitative proteomic analyses and identified proteomic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD029968 | Pride
Quantitative proteomics Ascl1 Lineage-specific oncoproteins Synergistic effect Pips Parp1 inhibitor Predictive biomarkers A histone demethylase Brca1/2 Small cell lung cancer Homologous recombination 
ProteomicsInduced Degradation of Lineage-specific Oncoproteins Underlies the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer
A subset of small cell lung cancer (SCLC) shows a clinical response to PARP inhibitors (PARPi) despite being proficient in homologous repair pathways. However, the underlying mechanism(s) of PARPi sensitivity is poorly understood. We performed quantitative proteomic analyses and identified proteomic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD029972 | Pride
Quantitative proteomics Ascl1 Lineage-specific oncoproteins Synergistic effect Pips Parp1 inhibitor Predictive biomarkers A histone demethylase Brca1/2 Small cell lung cancer Homologous recombination 
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