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GenomicConsortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

The data come from 40 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). CIMBA recruits individuals with pathogenic mutations in BRCA1 or BRCA2. The majority of carriers were recruited through cancer genetics clinics offering genetic testing, and were enroll...

phs001321 | dbGaP
Genomics237 HBOC Patients negative for BRCA1/2 mutations
237 HBOC Patients negative for BRCA1/2 mutations
PRJNA501883 | ENA
TranscriptomicsCGH profiles of primary breast carcinomas from HBOC (Hereditary Breast and Ovarian Cancer) families
89 tumors from women that were eligible for, and subjected to, routine diagnostic testing according to the HBOC criteria but were negative for pathogenic BRCA1/2-mutations or carried an UV in either BRCA1/2 A BRCA2-classifier was built using array-CGH profiles of 28 BRCA2-mutated and 28 sporadic bre...
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-22481 | biostudies-arrayexpress
GenomicsTAOK1 regulates chemo- and radiosensitivity in BRCA1/2-deficient tumors
TAOK1 regulates chemo- and radiosensitivity in BRCA1/2-deficient tumors
PRJEB102904 | ENA
ProteomicsHuman plasma LC-MSMS for identified protein biomarker for BRCA1/2 positive ovarian cancer
Ovarian cancer (OC) is the most lethal gynecologic malignancy, attributed by late diagnosis. Genetic alteration of BRCA1/2 was well known risk factors in people who does not occur ovarian cancer. There is a need for convenient and continuous diagnosis of ovarian cancer after genetic testing, and we ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD023508 | Pride
Human Lc-msms Brca carrier Plasma Ovarian cancer 
TranscriptomicsProfiling BRCA1, BRCA2 and non-BRCA1/2 LCLs post-Irradiation
The functional consequences of missense variants in disease genes are difficult to predict. We assessed if gene expression profiles could distinguish between BRCA1 or BRCA2 pathogenic truncating and missense mutation carriers and familial breast cancer cases whose disease was not attributable to BRC...
ORGANISM(S): Homo sapiens 
2008-03-21 | GSE10905 | GEO
GenomicsNon-breast/ovarian tumors in germline BRCA1/2 carriers
Non-breast/ovarian tumors in germline BRCA1/2 carriers
PRJNA995882 | ENA
GenomicsNon-breast/ovarian tumors in germline BRCA1/2 carriers
Non-breast/ovarian tumors in germline BRCA1/2 carriers
PRJNA995883 | ENA
TranscriptomicsNormal human mammary tissues from BRCA1 mutation carriers, non-BRCA1/2 mutation carriers and normal women
Gene expression profiles of normal human mammary tissue from BRCA1 mutation carriers, non-BRCA1/2 mutation carriers and normal women. RNA was prepared from normal breast tissue (confirmed by pathology) from reduction mammoplasties (n=5) and prophylactic mastectomies of known BRCA1 (n=7) and non-BRCA...
ORGANISM(S): Homo sapiens 
2009-08-01 | GSE17072 | GEO
GenomicsA transcription-based mechanism for oncogene-induced lethality in BRCA1/2-deficient cells [EdU-seq]
A transcription-based mechanism for oncogene-induced lethality in BRCA1/2-deficient cells [EdU-seq]
PRJNA643831 | ENA
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