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GenomicsPriming for Th2 differentiation requires IL-2-mediated induction of IL-4 receptor alpha chain expression
Th2 cells enable humoral immunity and host-defense to parasites. Whereas IL-4 drives Th2 differentiation and IL-2 is important later in this process by augmenting IL4 chromatin accessibility, we demonstrate that IL-2 serves an essential early role in regulating IL-4R? expression by inducing binding ...
ORGANISM(S): Mus musculus 
2008-12-11 | E-GEOD-12346 | biostudies-arrayexpress
UnknownTenogenic induction of human adipose-derived stem cells by soluble tendon extracellular matrix: composition and transcriptomic analyses.
Not available
S-EPMC9338462 | biostudies-literature
UnknownAnion Exchange Membrane Based on Interpenetrating Polymer Network with Ultrahigh Ion Conductivity and Excellent Stability for Alkaline Fuel Cell.
Not available
S-EPMC7243038 | biostudies-literature
GenomicsCytokine receptor modulation by interleukin-2 broadly regulates T helper cell lineage differentiation
T helper (Th) cells control host defense to pathogens. IL 12R expression is required for Th1, IL-4RM-NM-1 for Th2, and IL-6RM-NM-1/gp130 for Th17 differentiation to allow responsiveness to IL-12, IL-4, and IL-6, respectively. IL-2 via STAT5 controls Th2 differentiation by regulating the Th2 cytokine...
ORGANISM(S): Homo sapiens 
2011-04-24 | E-GEOD-27158 | biostudies-arrayexpress
UnknownImproving neurological outcome for acute basilar artery occlusion with sufficient recanalization after thrombectomy by intraarterial tenecteplase (INSIST-IT): Rationale and design.
Not available
S-EPMC10334187 | biostudies-literature
UnknownNRICM102, a TCM Formula, Attenuates COPD-Relevant Inflammatory Lung Injury in Mice by Improving Pulmonary Function and Reversing Immune Dysregulation
Not available
S-EPMC12944458 | biostudies-literature
TranscriptomicsThe prognostic and predictive value of a six-microRNA-based classifier in stage II colon cancer
microRNA profiling of colon tumor tissues vs adjacent normal tissues 40 paired tumor and adjacent normal tissues of stage M-bM-^EM-! colon caner
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-49246 | biostudies-arrayexpress
UnknownReversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids.
Not available
S-EPMC5594642 | biostudies-literature
GenomicsBATF-JUN is critical for IRF4-mediated transcription in T cells
Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune response. IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cell...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-39756 | biostudies-arrayexpress
UnknownDown-regulated γ-catenin expression is associated with tumor aggressiveness in esophageal cancer.
Not available
S-EPMC4024793 | biostudies-literature
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