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TranscriptomicsPromiscuity of enhancer, coding and non-coding transcription functions in ultraconserved sequence elements
The manuscript by D. Licastro and colleagues “Promiscuity of enhancer, coding and non-coding transcription functions in ultraconserved sequence elements” presents an overview of experimental and computational approaches employed by the authors to perform a multi-facet characterization of ultraconser...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-19371 | biostudies-arrayexpress
TranscriptomicsIdentification of novel tissue-specific transcription arising from E-cadherin/CDH1 intron2: a novel protein isoform increases gastric cancer cell invasion and angiogenesis.
E-cadherin, a protein encoded by the CDH1 gene is the dominant epithelial cell adhesion molecule playing a crucial role in epithelial tissue polarity and structural integrity. The progression of 90% or more carcinomas is believed to be mediated by disruption of normal E-cadherin expression, subcellu...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-32540 | biostudies-arrayexpress
TranscriptomicsDissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation
MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of highly invasive ...
ORGANISM(S): Homo sapiens 
2014-03-21 | E-GEOD-54611 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human foreskin fibroblasts cultured in media supplemented with human sera
Treatment of cultured cells with serum collected from humans on long-term calorie restriction enhances stress resistance in vitro. RNA expression was compared in human foreskin fibroblasts cultured in media supplemented with human sera obtained from: 1) healthy lean and weight-stable volunteers who ...
ORGANISM(S): Homo sapiens 
2013-09-04 | E-GEOD-41790 | biostudies-arrayexpress
TranscriptomicsExpression profiling of FRG1 transgenic mice.
RNA from skeletal muscle of mice over-expressing selectively in the skeletal muscle the gene FRG1, a candidate of facioscapulohumeral muscular dystrophy, was compared to RNA from skeletal muscle of WT mice. Total RNA obtained from isolated vastus lateralis muscles of 4 weeks old females WT mice and ...
ORGANISM(S): Mus musculus 
2013-09-04 | E-GEOD-28575 | biostudies-arrayexpress
TranscriptomicsTREM2 regulates microglial cell activation in response to demyelination in vivo
Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in hum...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-70475 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of Bmi1 overexpression in NSPC.
We have previously shown that conditional overexpression of Bmi1 in NSC increases their proliferation both in the developing neocortexand in the postnatal brain (Yadirgi et al. 2011). However, during embryonic development, increased and ectopic proliferation induced by overexpression of Bmi1 in prog...
ORGANISM(S): Mus musculus 
2012-11-12 | E-GEOD-31607 | biostudies-arrayexpress
TranscriptomicsMethylationEPIC array from fresh oral and oropharyngeal tissue samples from head and neck squamous cell carcinoma patients, tissue samples from potentially premalignant oral lesions and fresh tonsil tissue samples from control patients
This data was used to detect good biomarkers for head and neck squamous cell carcinoma and was integrated with transcriptome and miRNome data aiming to elucidate role of epigenetics on gene expression in head and neck squamous cell carcinoma.
ORGANISM(S): Homo sapiens 
2024-04-22 | E-MTAB-13954 | biostudies-arrayexpress
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