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ProteomicsResolving human α versus β cell fate allocation for the generation of stem cell-derived islets
Generating stem cell-derived glucagon-producing α and insulin-producing β cells allows to engineer in vitro biomimetics of the islet of Langerhans, the micro-organ controlling blood glucose; however, there is still a major knowledge gap in the mechanism by which human stem cell-derived α and β cells...
ORGANISM(S): Homo sapiens (Human) 
2026-05-19 | PXD064617 | Pride
Lc-msms 
TranscriptomicsRNA-seq of Pdx1-GFP+ sorted E10.5, wildtype and Hes1-/-. Neurog3-dependent Pancreas Dysgenesis Causes Ectopic Pancreas in Hes1 Mutants
RNA-seq of FACS Sorted E10.5 Pdx1-GFP+ of genotypes wildtype and Hes1-/-. Summary statement The developmental mechanisms that cause ectopic pancreas are poorly understood. We show that aberrant dorsal pancreas morphogenesis in Hes1 mutants leads to ectopic pancreas depending on the pro-endocrine ge...
ORGANISM(S): Mus musculus 
2018-08-20 | E-MTAB-6890 | biostudies-arrayexpress
TranscriptomicsIdentification of proliferative and mature β-cells in the islet of Langerhans
Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential1-5, thus understanding the mechanisms underlying this functional heterogeneity ...
ORGANISM(S): Mus musculus 
2016-06-02 | E-GEOD-68853 | biostudies-arrayexpress
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