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ProteomicsReprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: a novel path to cancer prevention
This study investigates the effects of Licochalcone A (LicA) on protein stability in breast cancer cells using Proteome Integral Solubility Alterations (PISA) proteomics. We treated MCF-7 (ER+) and MDA-MB-231 (ER-) cells with LicA (10 µM) for 24 hours and subjected them to temperature-dependent prot...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD061086 | Pride
Proteomics Licochalcone a Lipid metabolism Breast cancer prevention Lc-ms Srebp Antiproliferation Proteome integral solubility alterations (pisa) Pi3k-akt pathway Metabolic reprogramming Anti-inflammation 
TranscriptomicsStreptococcus suis 05ZY: control vs. treated by licochalcone A
Streptococcus suis is an important emerging worldwide pig pathogen and zoonotic agent with rapid evolution of virulence and drug resistance. Licochalcone A, used in traditional Chinese medicine, exhibits antimicrobial, antioxidant and anti-inflammatory activities. Herein, a whole-genome DNA microarr...
ORGANISM(S): Streptococcus suis 05ZYH33 
2013-05-07 | E-GEOD-46666 | biostudies-arrayexpress
TranscriptomicsPhenotype and expression profile analysis of Staphylococcus aureus biofilms and planktonic cells in response to Licochalcone A
Staphylococcus aureus (S. aureus) is one of the most important pathogens in humans and animals. The formation of S. aureus biofilm is considered an important mechanism of antimicrobial resistance. Therefore, finding effective drugs against the biofilm produced by S. aureus has been a high priority. ...
ORGANISM(S): Staphylococcus aureus 
2014-07-01 | E-GEOD-58938 | biostudies-arrayexpress
GenomicsLicochalcone A suppresses the proliferation of sarcoma HT-1080 cells, as a selective R132C mutant IDH1 inhibitor
Licochalcone A suppresses the proliferation of sarcoma HT-1080 cells, as a selective R132C mutant IDH1 inhibitor
PRJNA573906 | ENA
TranscriptomicsStreptococcus suis 05ZY: control vs. treated by licochalcone A
Streptococcus suis is an important emerging worldwide pig pathogen and zoonotic agent with rapid evolution of virulence and drug resistance. Licochalcone A, used in traditional Chinese medicine, exhibits antimicrobial, antioxidant and anti-inflammatory activities. Herein, a whole-genome DNA microarr...
ORGANISM(S): Streptococcus suis 05ZYH33 
2013-05-07 | GSE46666 | GEO
TranscriptomicsLicochalcone A suppresses the proliferation of sarcoma HT-1080 cells, as a selective R132C mutant IDH1 inhibitor
IDH1 mutations are closely related to the development and progression of various human cancers, such as glioblastoma, sarcoma, and acute myeloid leukemia. By screening dozens of reported natural compounds using both wild-type and mutant IDH1 enzymatic assays, we discovered Licochalcone A is a select...
ORGANISM(S): Homo sapiens 
2019-10-24 | GSE137934 | GEO
GenomicsLicochalcone A activate glycolysis by via PI3K / AKT pathway to play an anti-aging effect on adipose stem cells and aging mice [hADSCs]
Licochalcone A activate glycolysis by via PI3K / AKT pathway to play an anti-aging effect on adipose stem cells and aging mice [hADSCs]
PRJNA602840 | ENA
GenomicsLicochalcone A activate glycolysis by via PI3K / AKT pathway to play an anti-aging effect on adipose stem cells and aging mice [hippocampus]
Licochalcone A activate glycolysis by via PI3K / AKT pathway to play an anti-aging effect on adipose stem cells and aging mice [hippocampus]
PRJNA602809 | ENA
TranscriptomicsPhenotype and expression profile analysis of Staphylococcus aureus biofilms and planktonic cells in response to Licochalcone A
Staphylococcus aureus (S. aureus) is one of the most important pathogens in humans and animals. The formation of S. aureus biofilm is considered an important mechanism of antimicrobial resistance. Therefore, finding effective drugs against the biofilm produced by S. aureus has been a high priority. ...
ORGANISM(S): Staphylococcus aureus 
2014-07-01 | GSE58938 | GEO
TranscriptomicsLicochalcone A activate glycolysis by via PI3K / AKT pathway to play an anti-aging effect on adipose stem cells and aging mice [hADSCs]
We implemented transcriptomic analyses of hADSCs treated with Licochalcone A 6 days
ORGANISM(S): Homo sapiens 
2022-01-21 | GSE144122 | GEO
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